DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20190145

Effect of turmeric on alloxan induced diabetes mellitus in albino rats

Mugdha Rajeeva Padhye, Sangita Devrao Jogdand

Abstract


Background: Diabetes mellitus is a chronic metabolic disorder of glucose metabolism characterised by hyperglycaemia. Long standing diabetes mellitus leads to various complications affecting multiple organ systems. Management of diabetes mellitus includes lifestyle modification and pharmacotherapy. Pharmacotherapy of diabetes mellitus includes a wide variety of drugs that help in achieving adequate glycaemic control. Anti-diabetic medications are however associated with several adverse effects. Phytochemicals are being used extensively for the treatment of various diseases. Use of phytochemicals would minimize adverse effects due to various anti-diabetic drugs and improve patient compliance. In the present study, authors studied the effect of turmeric on alloxan induced diabetes mellitus in albino rats.

Methods: Albino Wistar rats of either sex weighing 180 - 250grams were utilized for the present study. Diabetes mellitus was induced by intraperitoneal administration of alloxan. Ethanolic extract of turmeric was administered to diabetic rats daily orally for duration of 28 days. Blood glucose levels were monitored using glucometer before and after intervention with turmeric.

Results: Statistically significant reduction in mean blood glucose levels (p value <0.05) was seen after intervention with turmeric in diabetic rats. There was a significant reduction in mean blood glucose levels.

Conclusions: Ethanolic extract of turmeric showed antihyperglycemic effect in diabetic rats.

Keywords


Alloxan, Diabetes mellitus, Phytochemicals

Full Text:

PDF

References


Madhu S, Srivastava S. Diabetes Mellitus: Diagnosis and Management Guidelines. 2015;28(1):4.

Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014 Feb;103(2):137-49.

Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-a concise review. Saudi Pharmaceut J. 2016 Sep;24(5):547-53.

Ahangarpour A, Oroojan AA, Khorsandi L, Kouchak M, Badavi M. Solid lipid nanoparticles of myricitrin have antioxidant and antidiabetic effects on streptozotocin-nicotinamide-induced diabetic model and myotube cell of male mouse. Oxidative Med Cellular Longevity. 2018;2018.

Silva TBC, Almeida PHRF, Araújo VE, Acurcio F de A, Guerra Júnior AA, Godman B, et al. Effectiveness and safety of insulin glargine versus detemir analysis in patients with type 1 diabetes: systematic review and meta-analysis. Ther Adv Endocrinol Metab. 2018 Jun 22;9(8):241-54.

Ighodaro OM, Adeosun AM, Akinloye OA. Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina. 2017 Jan 1;53(6):365-74.

Zhang DW, Fu M, Gao SH, Liu JL. Curcumin and diabetes: a systematic review. Evidence-Based Complementary Alternative Med. 2013;2013.

Ghorbani Z, Hekmatdoost A, Mirmiran P. Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin. Int J Endocrinol Metabol. 2014 Oct;12(4).

Mohammed A, Islam MS. Spice-derived bioactive ingredients: potential agents or food adjuvant in the management of diabetes mellitus. Frontiers Pharmacol. 2018;9:893.

Maithili Karpaga Selvi N, Sridhar MG, Swaminathan RP, Sripradha R. Curcumin attenuates oxidative stress and activation of redox-sensitive kinases in high fructose-and high-fat-fed male Wistar rats. Sci Pharmaceut. 2014 Nov 4;83(1):159-75.