Effects of resveratrol on oxidative stress in high fat diet /streptozocin induced diabetic wistar albino rats


  • Smita Das Department of Pharmacology, IMS & SUM Hospital, SOA (deemed to be University), Bhubaneswar, Odisha, India
  • Jayanti Prava Behera Department of Pharmacology, MKCG Medical College, Berhampur, Odisha, India
  • Y. Rojaramani Department of Pharmacology, SLN Medical College, Koraput, Odisha, India
  • Rashmi Ranjan Mohanty Department of Medicine, AIIMS, Bhubaneswar, Odisha, India




Diabetes, Oxidative stress, Resveratrol


Background: Diabetes mellitus is a common chronic disease. One of the pathophysiology is found to be oxidative stress. This study aims to evaluate the effect of resveratrol on oxidative stress in high fat diet (HFD)/streptozotocin induced diabetic rats.

Methods: Wistar albino rats, fed with HFD rendered diabetic with streptozotocin, were divided into 6 groups, namely the diabetic control treated with vehicle (DC), standard control which received metformin (SC), test groups treated with 5,10, and 20 mg/kg b.w. of resveratrol and combination of half dose of metformin and resveratrol (10 mg/kg)(TC). A group of six normal animals served as normal control (NC), another six as HFD control. Fasting blood glucose, lipid profile and serum MDA and SOD were measured one week after induction of diabetes. The animals were then treated orally for 2 weeks after which the same parameters were repeated. The in-vivo results were analysed by one way ANOVA followed by Tukey’s multiple comparison test.

Results: The DC group demonstrated a increase in the fasting blood glucose compared to NC, HFD control while a significant decrease in the fasting blood glucose was observed with SC, Test groups (p<0.05) as compared to the DC group. TC showed a significant improvement in dyslipidemia compared to their baseline values (p<0.05). There was significant change in the serum MDA level and SOD activity.

Conclusions: Resveratrol improves oxidative stress in diabetic rats.


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How to Cite

Das, S., Behera, J. P., Rojaramani, Y., & Mohanty, R. R. (2019). Effects of resveratrol on oxidative stress in high fat diet /streptozocin induced diabetic wistar albino rats. International Journal of Basic & Clinical Pharmacology, 8(3), 482–487. https://doi.org/10.18203/2319-2003.ijbcp20190651



Original Research Articles