A prospective evaluation of efficacy and safety of topical bromfenac 0.09% over topical flurbiprofen 0.03% after cataract surgery

Sahana K. Hebbar; Deepak P.; Nalini G. K.; Kavitha C. V.; Sahana G. N.; Jayashree V. Nagaral

doi:10.18203/2319-2003.ijbcp20190140

Authors

Sahana K. Hebbar Department of Pharmacology, HIMS, Hassan, Karnataka, India
Deepak P. Department of Pharmacology, HIMS, Hassan, Karnataka, India
Nalini G. K. Department of Pharmacology, HIMS, Hassan, Karnataka, India
Kavitha C. V. Department of Ophthalmology, HIMS, Hassan, Karnataka, India
Sahana G. N. Department of Pharmacology, HIMS, Hassan, Karnataka, India
Jayashree V. Nagaral Department of Pharmacology, HIMS, Hassan, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20190140

Keywords:

Anterior chamber inflammation, Bromfenac, Flurbiprofen, Post-operative pain, Prostaglandins

Abstract

Background: Different medications are used to reduce pain and inflammation after cataract surgery. Hence this study was taken up to compare the efficacy and safety of topical bromfenac 0.09% over topical flurbiprofen 0.03% in reducing anterior chamber inflammation and pain after cataract surgery.

Methods: Total of 100 patients who underwent uneventful cataract surgery with posterior chamber intra ocular lens (IOL) implantation were randomly allocated to receive bromfenac 0.09% and flurbiprofen 0.03% topically from first post-operative day onwards for 6 weeks. Assessment of anterior chamber inflammation and pain was done by slit lamp and visual analogue scale respectively on each follow up days. Analysis was done by unpaired t test and Fischer’s exact test.

Results: The response to treatment was earlier in bromfenac group for all the inflammatory changes (significant difference was found on day 7, p<0.05) except for corneal edema where both the groups showed similar response. On 7^th day after surgery, 72% patients in flurbiprofen group and 12% in bromfenac group had pain (score1), while on the 14^th day none in the bromfenac group complained of pain whereas 4% in flurbiprofen group still had pain. Both the drugs were safe and no clinically serious adverse effects were observed in either of the groups.

Conclusions: This study showed both the medications, topical bromfenac 0.09% and topical flurbiprofen 0.03% effective and safe in reducing pain and anterior chamber inflammation after cataract surgery but the response was earlier with bromfenac 0.09%.

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