Evaluation of anticonvulsant activity of aqueous extract of Adhatoda vasica leaves by MES model in rats

Authors

  • Sumitha A. Department of Pharmacology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India
  • Saranya R. Department of Pharmacology, Madha Medical College, Chennai, Tamil Nadu, India
  • Dhanasekaran R. Department of Paediatrics, Madras Medical College and Hospital, Chennai, Tamil Nadu, India
  • Geetha M. Department of Pharmacology, JJM Medical College, Davangere, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20185175

Keywords:

Adhatoda vasica, Anticonvulsant, Aqueous extract, MES

Abstract

Background: Epilepsy is the commonest neurological condition affecting people of all ages, race and social class. The present study was taken up to evaluate the anticonvulsant effect of aqueous extract of leaves of Adhatoda vasica in rats. To evaluate the effect of aqueous extract of Adhatoda vasica leaves on maximal electroshock model in albino rats and to compare the effect of aqueous extract of Adhatoda vasica leaves with standard dose of Phenytoin on Maximal electro shock model.

Methods: Anticonvulsant activity of aqueous extract of Adhatoda vasica was analysed using MES (Maximal electroshock) model. Phenytoin (25mg/kg) as standard for Maximal electroshock, and two doses of aqueous extract of Adhatoda vasica (100mg/kg and 200mg/kg) were used as test drugs. Parameters observed in MES were abolition of hind limb tonic extension (HLTE) and time taken to regain righting reflex.

Results: In MES model, control group showed 0% protection and standard phenytoin group showed 100% protection. Aqueous extract of Adhatoda vasica at 100mg/kg and 200mg/kg showed 33.33% and 50% protection from seizures respectively. The mean duration of time to regain righting reflex was significantly reduced in Adhatoda vasica groups when compared to control group (p <0.001). When groups 100mg/kg and 200mg/kg of Adhatoda vasica were compared for mean difference in the duration of time to regain righting reflex, statistically non-significant results (p >0.05) were obtained.

Conclusions: Aqueous extract of leaves of Adhatoda vasica has shown significant anticonvulsant action in MES model.

References

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Published

2018-12-24

How to Cite

A., S., R., S., R., D., & M., G. (2018). Evaluation of anticonvulsant activity of aqueous extract of Adhatoda vasica leaves by MES model in rats. International Journal of Basic & Clinical Pharmacology, 8(1), 153–156. https://doi.org/10.18203/2319-2003.ijbcp20185175

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Original Research Articles