Study of prescription patterns of antihypertensive agents in preeclampsia patients: Central India study

Authors

  • Shreya Shekhar Department of Pharmacology, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India
  • Tanaji R. Shende Department of Pharmacology, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India
  • A. S. Borkar Department of Pharmacology, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India
  • Riyaz Siddiqui Department of Pharmacology, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India
  • Sulabha A. Joshi Department of Obstetrics and Gynaecology, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20190650

Keywords:

Antihypertensives, Hypertension, Preeclampsia

Abstract

Background: The main objective of this study was to evaluate prescription patterns of antihypertensives in preeclampsia patients at a tertiary care hospital in Central India.

Methods: The study belongs to retrospective observational type. he study was conducted by department of Pharmacology in association of department of Obstetrics & Gynaecology department at Nkp Salve Institute of Medical Sciences & Research Centre, Lata Mangeshkar Hospital, Nagpur. Permission from Institute Ethics Committee was taken for studying the prescribing patterns of drugs. The study was conducted for a period of 6 months. Inclusion and Exclusion criteria were added.

Results: The maximum number patients seen in age groups 36-41 (28.6%). The main drug prescribed in our study was Labetalol followed by methyldopa. In our study most of the patients were of moderate and mild type corresponding to 48% and 32% respectively and only 20% of patients belong to severe cases. In our study highest number of patients was seen in second gravida i.e. 33.33%.

Conclusions: Labetalol was the most common anti hypertensive prescribed in pre eclampsia patients. Rationale prescribing of drugs were done.

Author Biography

A. S. Borkar, Department of Pharmacology, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India

 

 

References

Redman CW. Hypertension in pregnancy:the NICE guidelines. Heart. 2011;97:1967-9.

Roberts J, Pearson G, Cutler J, Lindheimer M. Summary of the NHLBI working group on research on hypertension during pregnancy. Hypertens. 2003;41(3):437-45.

Shrank WH, Hoang T, Ettner SL, et al. The implications of choice:prescribing generic or preferred pharmaceuticals improves medication adherence for chronic conditions. Arch Intern Med. 2006;166(3):332–7.

Lambert G, Brichant JF, Hartstein G, Bonhomme V, Dewandre PY. Preeclampsia: an update. Acta Anaesthesiol Belg. 2014;65(4):137-49.

Yamakanamardi S, Anuradha HV, Sujani BK, Shivamurthy MC. Analysis of prescribing pattern of antihypertensive drugs during pregnancy and neonatal outcome in a tertiary care centre. Int J Basic Clin Pharmacol. 2016;5:718-21.

Folic M, Folic N, Varjacic M, Jakovljevic M, Jankovic S. Antihypertensive drug therapy for hypertensive disorders in pregnancy. Acta Medica Medianae. 2008;47(3):67-71

T Naveen Kumar, Tadvi NA, Kaul R. Prescription pattern of drugs in pregnancy induced hypertension in a tertiary care hospital. Int J Basic Clin Pharmacol 2013;2:783-7.

JNC 7 express. The seventh report of the Joint National committee on prevention, detection, evaluation and treatment of high blood pressure. Available at: http://www.nhlbi.nih.gov/guidelines/ hypertension/ex press.pdf. Accessed on 28 January 2016.

Kauntiz AM, Hughes JM, Grimes DH, Smith JC, Rochat RW, Kaffrissen ME. Causes of maternal mortality in the United States of America. J Obstetr Gynecol. 1985;65:605-12.

Sheraz S, Shahzad S, Boota M. Eclampsia. Prof Med J. 2006;13(1):27-31.

Zibaeenazhad MJ, M Ghodsi P Arab, Gholzom N. the prevalence of hypertensive disorders of pregnancy in Shiraz, Southern Iran; Iranian Cardiovascular Res J. 2010;4:169-72.

Sajith M, Nimbargi V, Modi A, Sumariya R, Pawar A. Incidence of pregnancy induced hypertension and prescription pattern of antihypertensive drugs in pregnancy. Int J Pharma Sci Res. 2014;23:4.

Ramkumar K, Anju AS, Kandel P, Vishwanath BA, Kumar P. A study on prescribing pattern of antihypertensive drugs during pregnancy in tertiary care hospital, banglore. Indo Am J Pharm Res. 2016;6;09:6537-46.

Gersak K, Cvijic M, Cerar LK. Angiotensin II receptor blockers in pregnancy:a report of five cases. Reprod Toxicol. 2009;28(1):109-12.

Girija SD. Labetalol-An emerging first line drug for pregnancy induced hypertension. Indian J Clin Prac. 2013;23:640-1.

Abalos E, Duley L, Steyn DW, Henderson-smart DJ. Antihypertensive drug therapy to mild to moderate hypertension during pregnancy. Cochrane Database Syst Rev. 2003;1:CD002252.

Downloads

Published

2019-02-23

How to Cite

Shekhar, S., Shende, T. R., Borkar, A. S., Siddiqui, R., & Joshi, S. A. (2019). Study of prescription patterns of antihypertensive agents in preeclampsia patients: Central India study. International Journal of Basic & Clinical Pharmacology, 8(3), 478–481. https://doi.org/10.18203/2319-2003.ijbcp20190650

Issue

Section

Original Research Articles