Socio-demographic profile of multi-drug resistant tuberculosis patients and its association with severity of adverse drug reactions in DOTS plus centre at tertiary hospital in Himachal Pradesh, India

Authors

  • Anita Kumari Department of Pharmacology, Dr. YSP Government Medical College, Nahan, Himachal Pradesh, India
  • Parveen K. Sharma Department of Pharmacology, SLBS Government Medical College Mandi at Nechowk, Himachal Pradesh, India
  • Dinesh Kansal Department of Pharmacology, Dr. RP Government Medical College, Kangra, Tanda, Himachal Pradesh, India
  • Rekha Bansal Department of Pulmonary Medicine, Dr. RP Government Medical College, Kangra, Tanda, Himachal Pradesh, India
  • Sumita Kumari Department of Community Medicine, Dr. YSP Government Medical College, Nahan Himachal Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20184843

Keywords:

Multi-drug resistant tuberculosis, Severity of adverse drug reactions, Socio-demographic profile

Abstract

Background: Multi-drug resistant tuberculosis has become major public health problem and obstacle to effective control of tuberculosis. Objectives was to study the socio-demographic profile of multi- drug resistant tuberculosis patients and its association with severity of ADR (adverse drug reactions) in DOTS plus centre at tertiary hospital in Himachal Pradesh.

Methods: It was a prospective observational study carried out from November 2012 to October 2013 on multi-drug resistant tuberculosis (MDR-TB) patients after approved from Institutional Ethics Committee.

Results: Out of 104 patients the mean age of patients was 39.9 ±14.26 years. Majority of the patients were in the economically productive age groups. Multi-drug resistant tuberculosis was more in male (76%) than female (24%) and 96% of patients were belonged to rural area. The educational status of the MDR-TB shows 24% patients were illiterate. 63.46% MDR-TB patients were underweight (BMI<18.5%) according to WHO guidelines for obesity. Severity of ADR assessed by Hart wig and Siegel’s scale showed 21% patients experienced mild ADRs, 49% patients had moderate and 17% patients had severe ADRs. Severity of ADR is seen more in male, economically productive age group, subjects on vegetarian diet, patients who were underweight (BMI<18.5%) and with lower educational status.

Conclusions: MDR-TB is a rapidly increasing health problem with major socio-economic and individual consequences. Multi-drug resistant tuberculosis mainly affects middle age that is in the economically productive age group which hampers the social and economic development of individual, society and nation.

References

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Published

2018-11-24

How to Cite

Kumari, A., Sharma, P. K., Kansal, D., Bansal, R., & Kumari, S. (2018). Socio-demographic profile of multi-drug resistant tuberculosis patients and its association with severity of adverse drug reactions in DOTS plus centre at tertiary hospital in Himachal Pradesh, India. International Journal of Basic & Clinical Pharmacology, 7(12), 2342–2346. https://doi.org/10.18203/2319-2003.ijbcp20184843

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Original Research Articles