Phenytoin induced Stevens Johnson syndrome: a case report

Authors

  • Bharadwaja Pendurthi Department of Pharmacology, Mysore Medical College & Research Institute, Mysore, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20182107

Keywords:

Adverse drug reactions, Phenytoin, Pharmacovigilance, SJS

Abstract

Stevens-Johnson syndrome (SJS) is a rare consequence of hypersensitivity reaction precipitated by certain drugs and viral infections. It is an idiosyncratic drug reaction usually associated with drugs like anti-epileptics, non-steroidal anti-inflammatory compounds and antibiotics. The overall incidence of this entity is very low and is life-threatening if undiagnosed and untreated. The syndrome is characterized by purpuric macules and bullous eruptions involving the mucous membrane which may be followed by systemic manifestations. The mechanism of SJS due to drugs is not fully defined. Delayed Hypersensitivity reaction mediated by T lymphocytes in response to a drug is thought to be responsible. Here authors present a case of SJS induced by phenytoin in an adult male. The case warrants the need of adopting a meticulous approach while prescribing phenytoin. The case is being reported to accentuate the importance of adverse drug reactions and to emphasize the importance of reporting such reactions ensuring efficient pharmacovigilance.

References

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Published

2018-05-22

How to Cite

Pendurthi, B. (2018). Phenytoin induced Stevens Johnson syndrome: a case report. International Journal of Basic & Clinical Pharmacology, 7(6), 1205–1207. https://doi.org/10.18203/2319-2003.ijbcp20182107

Issue

Section

Case Reports