Comparative prospective randomized open label trial of synbiotic (bifilac) as an add on therapy with standard treatment in patients with aphthous ulcer

Authors

  • Sasikala G. Department of Pharmacology, Kilpauk Medical College and Hospital, Chennai, Tamil Nadu, India
  • Malar Sivaraman Department of Pharmacology, Kilpauk Medical College and Hospital, Chennai, Tamil Nadu, India
  • Trayambak Dutta Department of Medical and Scientific Affairs, Tablets India Ltd, Chennai, Tamil Nadu, India
  • Dhanasekar K. R. Department of Medical and Scientific Affairs, Tablets India Ltd, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20181628

Keywords:

Analgesics, Aphthous ulcer, Synbiotic, Lozenges

Abstract

Background: To trial the safety, efficacy and rapidity of response to a lozenges containing synbiotic in patients with minor aphthous ulcer.

Methods: A total of 60 patients were enrolled for the trial after obtaining IEC approval and randomly allocated into two groups. Control “Group A” was administered with conventional treatment i.e., zytee and B complex for 2 weeks and trial “Group B” was administered with Bifilac along with conventional treatment for 2 weeks. The results of this trial were analyzed both subjectively and objectively.

Results: Comparing with control group, where standard treatment was used with analgesics and B-complex, the trial group showed a quick relief of pain and helped in reducing mean size of ulcer.

Conclusions: This trial was done with synbiotic lozenges in minor aphthous ulcers and it proved to be better alternative for them. Moreover, synbiotics have no adverse effects.

References

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Published

2018-04-23

How to Cite

G., S., Sivaraman, M., Dutta, T., & K. R., D. (2018). Comparative prospective randomized open label trial of synbiotic (bifilac) as an add on therapy with standard treatment in patients with aphthous ulcer. International Journal of Basic & Clinical Pharmacology, 7(5), 878–881. https://doi.org/10.18203/2319-2003.ijbcp20181628

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Section

Original Research Articles