DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20160463

Screening of benzofuran compound 3-acetamido-2-p-anisoyl benzofuran for anti-inflammatory activity in acute models of inflammation

Lakshminarayana K., Umesh G. Wari, Suresh S. Kendri

Abstract


Background: Benzofurans are colourless solid compounds which are derived from coal tar. They have been shown to have many properties which are relevant to the field of pharmacology. For example they have significant antibacterial, antifungal, antidepressant and anti-arrhythmic properties. In some of the studies carried out on them they have shown to have anti-inflammatory activity also. So this study was conducted to know if the compound 3-acetamido-2-p-anisoyl benzofuran has anti-inflammatory activity in acute inflammation.

Methods: The benzofuran compound understudy and phenylbutazone were administered orally to wistar albino rats in the dose of 100 mg/kg body weight, with 2% gum acacia as suspending agent and the effects were observed in acute models of inflammation viz, carrageenin induced rat paw edema, and turpentine induced peritonitis.

Results: The results of our study showed that the benzofuran compound under study has significant anti-inflammatory activity in both the experimental models of acute inflammation.

Conclusions: Results from our study show that the compound under study has significant anti-inflammatory activity and further detailed works with this compound in different doses are needed.


Keywords


Acute inflammation, Benzofurans, Carrageenin, Phenylbutazone, Turpentine, Peritonitis

Full Text:

PDF

References


Kirilmis C, Ahmedzade M, Servi S, Koca M, Kizirgil A, Kazaz C. Synthesis and antimicrobial activity of some novel derivatives of benzofuran: part 2. The synthesis and antimicrobial activity of some novel 1-(-1-benzofuran-2-yl)-2-mesitylethanone derivatives. Eur J Med Chem. 2008;43(2):300-8.

Shazia NA, Philip CS, Daniel RH. Synthesis of cicerofuron an antifungal benzofuran and some related analogues. Tetrahedron. 2006;62:4214-26.

Malik WU, Mahesh VK, Raishgani M. Synthesis and biological evaluation of some benzofuran derivatives. Indian J Chem. 1971;9:655.

Bourgery G, Dostert P, Lacour A, Langlois M, Pourrias B, Tisne-Versailles J. Synthesis and antiarrhythmic activity of new benzofuran derivatives. J Med Chem. 1981;24(2):159-67.

Balasaheb JM, Agasimundin YS. Microwave assisted synthesis of benzofuran analogues of fenamates as NSAIDS. J Child Chem Soc. 2009;54(1):77-9.

Mitchell RN, Cotran RS. In: Robbins Basic Pathology 7th Edition. Philadelphia: Elsevier-Health Publications. 2002:33.

Tripathi KD. In: Essentials of Medical Pharmacology. 7 th Edition. New Delhi: Jaypee Brothers Medical Publishers. 2013:193.

Chakrabarti JK, Eggeleton RJ, Gallagher PT, Harvey J, Hicks TA, Kitchen EA. 5-Acyl -3-substituted – benzofuran -2(3H) – ones as potential anti-inflammatory agents. J Med Chem. 1987;30(9):1663-8.

Wagner W, Khanna P. In: Katzungs Basic and Clinical Pharmacology. 9th edition. New York: McGraw Hill. 2001:586.