DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20180670

Prescription pattern of antiepileptic drugs in indoor patients at tertiary care hospital in Haryana, India

Arvind Narwat, Vivek Sharma

Abstract


Background: Epilepsy is a challenging medical problem in India with an annual incidence of 27.27 per 100,000 population and prevalence of 572.8 per 100,000. People with epilepsy require prolonged treatment and monitoring. The main goal in the treatment of epilepsy should be adequate control of seizures, without causing any life-threatening reactions due to the medications. This study was done to get an insight into the prescription pattern of anti-epileptic drugs (AEDs) in different types of epilepsy.

Methods: A prospective study was carried out for six months (Feb to June 2016) in admitted patients in super speciality ward (Lala Shyam Lal) in neurology department of PGIMS, Rohtak, Haryana. The prescription data of 100 patients of seizures was analysed.

Results: Idiopathic generalised epilepsy was commonest type of epilepsy (42%) and sodium valproate was the commonest drug prescribed for its treatment (66.66%) followed by phenytoin (23.33%) Symptomatic epilepsy was second commonest seizure (30%) and phenytoin (60%) was the commonest drug prescribed for it followed by sodium valproate (30%). Common adverse effects associated with anti-epileptic drugs (AEDs) were nausea, drowsiness, weight gain, diplopia and ataxia.

Conclusions: Idiopathic generalized epilepsy was the commonest type of epilepsy recorded and sodium valproate was the commonest prescribed drug.


Keywords


Anti epileptic drugs, ADRs, Drug prescription, Epilepsy, IRUD, INRUD

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References


How Common is Epilepsy in South-East Asia? Some facts and figures on Epilepsy. Available at: http://tinyurl.com/ngcl4bd.

Banerjee TK, Ray BK, Das SK. A longitudinal study of epilepsy in Kolkata, India. Epilepsia. 2010;51(12):2384-91.

Cloyd JC, Remmel RP. Antiepileptic drug pharmacokinetics and interactions: impact on treatment of epilepsy. Pharmacotherapy 2000;2(8):139-51.

Foletti GB. Clinical utilization of new anti-epileptic agents. Rev Med Suisse Romande 2000;120(9):703-7.

How to investigate drug use in health facilities: selected drug use indicators. Geneva, World Health Organization; 1993 (EDM Research Series No. 007).

Mathur S, Sen S, Ramesh L, Kumar S. Utilization pattern of antiepileptic drugs and their adverse effects, in a teaching hospital. Asian J Pharmaceut Clin Res. 2010;3(1):55-9.

George J, Jose J, Kulkarni DA, Hanamantappa RR, Shalavadi CV. Evaluation of Drug Utilization and Analysis of Anti-Epileptic Drugs at Tertiary Care Teaching Hospital. Indian Journal of Pharmacy Practice. 2016 Jul;9(3):189.

Meenakshi B. An analysis of prescription pattern and adverse drug reaction profile in children treated with antiepileptic drugs in a tertiary care teaching hospital. Int J Basic Clin Pharmacol. 2016;5(2):389-93.

Guidelines on the use of international nonproprietary names (INNs) for pharmaceutical substances. Geneva, World Health Organization, 1997.

Fattouh R, Hamad AB. Impact of using essential drug list: analysis of drug use indicators in Gaza Strip. East Mediterr Health J. 2010;16(8):886-92.

Naseeb TA, Nasser MA. Drug prescribing indicators in primary health care centers in Bahrain. Saudi Med J. 2005;26(9):1436-38.