Venlafaxine induced hepatotoxicity in a carcinoma of breast survivor with co-morbid depression

Authors

  • Rajnish Raj Department of Psychiatry, Government Medical College and Rajindra Hospital, Patiala 147001, Punjab, India
  • Nisha Bhagat Department of Obstetrics and Gynecology, Government Medical College and Rajindra Hospital, Patiala 147001, Punjab, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20174390

Keywords:

Drug induced liver injury, Depression, Hot flashes, Venlafaxine

Abstract

Drug Induced Liver Injury (DILI) is one of the leading causes of liver damage worldwide and raises concerns about its prescription in lieu of the limited drug options available for the depression. Venlafaxine (VEN) is an antidepressant with dual neurotransmitter receptor modulations i.e., serotonin and norepinephrine reuptake inhibitor (SNRI) and having an additional benefit in management of vasomotor symptoms especially in menopausal patients where hormone replacement therapy (HRT) is contraindicated. VEN induced hepatotoxicity have been reported to occur in less than 1% of patients. Until now, less than 11 cases of VEN-related liver injuries have been reported in literature. We hereby, report a rare case of VEN induced liver injury in a 40-year-old breast cancer survivor with co-morbid depression.

References

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Published

2017-09-23

How to Cite

Raj, R., & Bhagat, N. (2017). Venlafaxine induced hepatotoxicity in a carcinoma of breast survivor with co-morbid depression. International Journal of Basic & Clinical Pharmacology, 6(10), 2534–2536. https://doi.org/10.18203/2319-2003.ijbcp20174390

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Section

Case Reports