DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20172725

A study of efficacy and safety of intravenous iron sucrose for the treatment of moderate anaemia in antenatal women in South India

Venkata Ramana Vundi, Madhavi Pudutha, Chandrakala Kambar

Abstract


Background: Iron deficiency anaemia in pregnancy is a common medical problem throughout India with the burden of disease impacting on both mother and the newborn. The WHO technical group working on the prevention and treatment of anaemia has documented that parenteral iron therapy has produced a rapid and better correction of iron deficiency anaemia.

Methods: A total of 61 antenatal women in the age group of 18-25yrs were enrolled and randomly assigned into study group. For a period of 4 weeks, study group received iron sucrose intravenously. The results were noted, tabulated, analysed and expressed as descriptive statistics. Student's ‘t’ test and percentages were compared using chi square test. P -value, <0.001 was considered significant. The results were analysed by using SPSS V-21 software.

Results: Mean rise of Hb was 2.51±0.44 with IV iron sucrose this was highly significant (HS). Mean rise of MCV was 8.02±6.72 with IV iron sucrose this was not significant (NS). Mean rise of PCV was5.7±2.77 with IV iron sucrose. These findings showed improvement in Hb and PCV which were statistically highly significant (HS). Adverse effects were 14% in the group.

Conclusions: The present study proved that iron sucrose when given intravenously there was a rapid improvement in anaemia. IV iron sucrose was proved to be safe with minimal side effects.


Keywords


Haemoglobin, Iron deficiency anaemia, Mean corpuscular volume, Packed cell volume

Full Text:

PDF

References


UNICEFUNOWHO GENEVA. Iron deficiency anaemia, assessment, prevention and control, 2001.

Noronha JA, Bhaduri A, Bhat VH. Prevalence of anemia among pregnant women: A community-based study in Udupi (D.t), Health and Population Perspectives and Issues. 2008;31(1):31-40.

Haider BA, Olofin I, Wang M, Spiegelman D, Ezzati M, Fawzi WW. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and Meta-analysis. BMJ. 2013 June;346:f3443.

Ivan EA, Mangaiarkkarasi A. Evaluation of Anaemia in Booked Antenatal Mothers during the Last Trimester. Journal of Clinical and Diagnosticresearch. 2013;7(11):2487-90.

Jiji DB, Rajagopal K. A Study to assess the pregnant women the knowledge and risk factors of anaemia among the pregnant women selected and attending Healthcare facilities in Sebha, Libya. Journal of Science. 2014;4(1):19-22.

Patra S, Pasrija S, Trivedi SS, Puri M. Maternal and Perinatal outcome in patients with severe anaemia in pregnancy. International Journal of Gynaecology and obstetrics. 2005;91:164-5.

Kalaivani K. Prevalence and consequences of anaemia in pregnancy. Indian J Med Res. 2009 Nov;130(5):627-33.

Scholl TO. Iron status during pregnancy: setting the stage for mother and infant. Am J. Clinc Nutr. 2005;81:1218S-22S.

Scot BS, George MR. Parental iron therapy option. Am J. 2004;76:74-8.

Chandler G, Harchowal J, Macdougall IC. Intravenous iron sucrose: establishing a safe dose. Am J Kidn Dis. 2001;38:988-91.

Protocol for the use of IV iron sucrose - Venofer® Page 2 of 11 Author: Transfusion practitioner VI.0 Approved by D&TC 23 January 2008.

Dutta DC. Medical illness complicating pregnancy, Textbook of Obstetrics, 6th Edition. [Ed Konar H] The central Book Agency Pvt Ltd. Culcutta; 2004:262- 271.

Dewan B, Philipose N, Balasubramanian A. Assessment of intravenous Iron Sucrose in the Management of Anemia in Gynecological and Obstetrical Practice. Obstet Gynaecol India. 2012 Jun;62(3):281-5.

Aggarwal RS, Mishra VV, Panchal NA, Patel NH, Deshchougule VV, Jasani AF. Evaluation of iron sucrose and oral iron in the management of Iron Deficiency Aaemia in pregnancy NJCM. 2012;93:415-16.

Kharde PS, Bangal VB, Panicker KK. Comparative study of intravenous iron sucrose versus oral iron therapy in postpartum period. IJBAR. 2012;89:102- 08.

Momen AI, Meshariet AK. Intravenous Iron sucrose complex in the treatment of iron deficiency anemia during pregnancy. Eur J Obstet Gynecol Reprod Biol. 1996;69:121-4.

Raja KS. Intravenous iron sucrose complex in iron deficiency anaemia in pregnancy. RWJ. 2003;216:64-9.

Bayoumeu F. Iron therapy in iron deficiency anaemia in pregnancy, intravenous route versus oral route. AM J obstetgynecol. 2002;186:518-212.