The effect of acetylation phenotype on the dynamic changes of indices of calcium metabolism and iron levels in liver detoxification on the background of experimental hypothyroidism

Authors

  • Saidamir Saidov Department of Pharmacology, Tashkent Pharmaceutical Institute, Tashkent 100147, Uzbekistan
  • Asilbek Ahmadjonuv Department of Pharmacology, Tashkent Pharmaceutical Institute, Tashkent 100147, Uzbekistan
  • Anvar Mavlonov Department of Pharmacology, Tashkent Pharmaceutical Institute, Tashkent 100147, Uzbekistan

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20171081

Keywords:

Acetylation, Calcium-phosphorus metabolism, Hypothyroidism, Iron, Liver detoxification

Abstract

Background: Some studies of the characteristics of the calcium-phosphorus metabolism changes in experimental hypothyroidism given the phenotype of acetylation will allow to more effectively diagnose, predict the course and to carry out prevention and treatment of hypothyroidism and the accompanying pathological changes.

The aim is to trace the dynamics of phosphorus-calcium metabolism and the level of serum iron in experimental hypothyroidism and to determine the severity of it changes depending on the type of acetylation.

Methods: In experiments were used rats weighing 180-220g, who were divided into 2 main groups depending on the type of acetylation on α - slow and β - fast metabolizer (acetylators). Each group was modelled experimental hypothyroidism by the introduction of mercazolil at a dose of 5 mg, for 14 days. Each group was divided into 5 subgroups depending on the time of the study. Group of α-slow metabolizers (acetylators) were divided into the following subgroups: Iα - intact IIα - at the 4th hour of the study, IIIα - on the 1st week of the study, IVα - 2-week studies, Vα - on the 3rd week of the study.

Results: In the study of the calcium concentration at the 4th hour of the study in subgroups with α - and β - acetylation phenotypes were observed the decrease by 12.0% and 10.5% respectively, and its level in the IIβ - subgroup was 5.3% lower than the IIα- subgroup. The concentration of calcium ions in Vα subgroup was lower than in the Iα sub-group was 12.0%, and the level of calcium in the blood serum of animals Vβ was lower compared to Iβ IIβ IIIβ Ivβ-90.9%, 72.7%, 80.0%, 80.9% respectively. Also relatively, Vα Vβ subgroups in the subgroup calcium concentration were lower at 81.8 percent.

Conclusions: Belonging to a particular phenotype of acetylation affects the degree of severity of the changes of indices of calcium-phosphorus metabolism and serum iron in experimental hypothyroidism, the most significant differences between the values of their indicators were detected early and deadlines of the study.

References

Goldenkova-Pavlova IV, Bruskin SA, Abdeev RM. Comparative analysis of the results of phenol typing and genotyping for the polymorphism of N-acetylation in humans. Genetics: Journal of Russian Academy of Sciences. 2006;42;8:1143-50.

Masalova NN, Zakharenko RV. State of calcium-phosphorus metabolism and bone metabolism in norm and at infringement of function of a thyroid gland. Eastern Medical Journal. 2009;2:122-5.

Orlova MM, Rodionova TI. Biochemical and immunological markers of dysfunction in hypothyroidism. Sibir Medical Journal - Saratov, 2011;26;4:20-3.

Poputnikov DM, Melenchuk EV, Vismont FI. Violations of water-electrolyte metabolism (pathophysiological aspects). Textbook Minsk, BSMU; 2011:38s.

Shantis AK, Romashchenko SV, Yapparov IA. Correction of experimental hypothyroidism new iodine-containing drug. The achievements of science and technology APC. 2012;7:72-5.

Manyuk ES, Izatullin VG, Vasilieva LS. Correction of experimental hypothyroidism with herbal preparation “Bayakon”. Bulletin of AUSC RAMS. 2008;59:54-7.

Tkachuk A. Clinical Biochemistry. ed. pers. corr. Russian Academy of Sciences, Academician of RAMS VA Tkachuk. - 2nd ed., Revised and edited. - M.: GEOTAR-MED; 2004;512.

Evgenyev MI, Harmonov SY, Gismyatov RG, Shitova NS, Zykov IE. Non-invasive methods of determination of acetylation phenotype. Issues of Biololgy, Medicine and pharmacist chemistry. 2003;3:34-9.

Nikitina LP, Solovyov NV, Tsidendambaev PB. Biochemistry of the liver in health and disease: a learning aid for teachers and medical students, physicians, interns, clinical residents. Chita CHGMA; 2004:52.

Fadeev VV. Modern concepts of the diagnosis and treatment of hypothyroidism in adults. Issues of Endocrinol. 2004;2:47-53.

Nikolaev AY. Biological Chemistry / AY Nikolaev. - 4th ed., Rev. and ext. M.: Medical news agency; 2004:556.

Downloads

Published

2017-03-25

How to Cite

Saidov, S., Ahmadjonuv, A., & Mavlonov, A. (2017). The effect of acetylation phenotype on the dynamic changes of indices of calcium metabolism and iron levels in liver detoxification on the background of experimental hypothyroidism. International Journal of Basic & Clinical Pharmacology, 6(4), 739–745. https://doi.org/10.18203/2319-2003.ijbcp20171081

Issue

Section

Original Research Articles