Comparison of postoperative analgesic efficacy and safety of parecoxib and ketorolac in patients of inguinal hernia

Authors

  • Ajit M. Zende Department of Pharmacology, R.C.S.M. Government Medical College and C.P.R. Hospital, Kolhapur-416 002, Maharashtra, India
  • Rama R. Bhosale Department of Pharmacology, R.C.S.M. Government Medical College and C.P.R. Hospital, Kolhapur-416 002, Maharashtra, India

Keywords:

Ketorolac, Parecoxib, Post-operative pain

Abstract

Background: The present study was conducted to compare postoperative analgesic efficacy and safety profile of intravenous parecoxib with intravenous ketorolac in patients operated for inguinal hernia.

Methods: It was six months, prospective, randomized parallel group, open label study in patients operated for inguinal hernia. Each patient was randomly assigned the analgesic drug treatment and was grouped as control group (ketorolac treated) and study group (parecoxib treated).

Results: The present study has shown that parecoxib has similar analgesic efficacy as that of ketorolac, with parecoxib having significant longer duration of analgesic action. Parecoxib sodium was well tolerated in all patients and most of patients rated parecoxib as well as ketorolac as either good or excellent.

Conclusions: The study demonstrated that parecoxib compares favorably with ketorolac and parecoxib can be recommended as a useful component of postoperative pain control in hernia surgery.

References

Zvonko Kucer. The objective measurement of the pain in orofacial surgery. Actastomatologica NAISSI;2003:19(41).

Rose DK, Cohen MM, Yee DA. Changing practice of pain management. Anesth Analg 1997;84:764-72.

Eileen P, Lynch, Marrissa A Lazor, Janice E Gallis, John Orav, Lee Goldmann and Edward R Marcantonia. Patient experience of pain after elective non-cardiac surgery. Anaesthesia analgesia 1997;85:117-23.

Judith S Walkar and John J Carmody. Experimental pain in healthy subjects: Gender differences in nociception and in response to ibuprofen. Anaesthesia analgesia 1998;86:1257-62.

Kuhel FA, Egan RW. Prostaglandins, arachidonic acid and inflammation. Science 1980;210:978-84.

Hawkey CJ. New drug classes COX–2 inhibitors. Lancet 1999;353:307-14.

Talley JJ, Bartenshaw SR, Brown DL, et al. parecoxib sodium a potent selective COX-2 inhibitor for parenteral administration. J Med Che 2000;43:1661-3.

Ormord D, Willington K, Wagstaff AJ. Valdecoxib. Drugs 2002;62(14):2059-71.

Raj P. The problem of postoperative pain: An epidemiologic perspective. In: Ferran FM and Vade Bncouer TR – Eds. Postoperative pain management. New York, Churchill Livingstone; 1993:2-3.

Brasseur L, Poisson – Salmon A S, Lory C, Chauvain M, Durieux P. Survey on postoperative pain prevalence and severity in the French largest public hospital group. British Journal of Anaesthesia 1996;76:129.

C Mammie, M Bernstein, A Morabia, E Klopfenstein, D Sloutskis and Forster. Are their reliable predictors of postoperative pain. Acta Anaesthesiologica Scandinavica 2004;48:234-42.

Mc Grath PA. Psychological effects of pain perception. In C Schechter NL, Berdo CB, Yesterm Eds. Psychological aspect of pain perception, pain in infants, children and adolescents. Baltimore: Williams and wilkins 1993:39-63.

J Romsing and S. Moiniche. A Systemic review of COX-2 inhibitors compared with traditional NSAIDs or different COX-2 inhibitors for postoperative pain. Acta Anaesthesiol Scandinavica 2004;48:525-46.

Lewis S. Ketorolac in Europe. Lancet 1994;343:784.

Essmat M, Hegazy MD, Nagala Abd EL – Hady MD, Mai Wedad, Abdullah MD. Comparative study of postoperative analgesic effects of parecoxib vs ketorolac and placebo in cervical disc surgery. Eng J Anaesth 2003;19:179-82.

Barton SF, Fred F, Michel C, Kuss ME, Diane BS, Shobha S, Richard C: Efficacy and safety of intravenous parecoxib sodium in relieving acute postoperative pain following gynecologic laparotomy surgery. Anaesthesiology 2002;97(2):306-14.

Daniels S E, Grossman EN, Kuss ME, et al. A double blind randomized comparison of IM and IV administered parecoxib sodium vs ketorolac and placebo in post-oral surgery pain model. Clinical Ther 2001;23:1-14.

Cheer SM, Goa KL. Parecoxib (parecoxib sodium). Drugs 2001;61:1133-41.

Kranke P, Morin AM, Roewer N, Eberhart LH. Patients' global evaluation of analgesia and safety of injected parecoxib for postoperative pain: a quantitative systematic review. Anesth Analg 2004;99:797-806.

Downloads

Published

2017-01-31

How to Cite

Zende, A. M., & Bhosale, R. R. (2017). Comparison of postoperative analgesic efficacy and safety of parecoxib and ketorolac in patients of inguinal hernia. International Journal of Basic & Clinical Pharmacology, 2(4), 414–420. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1292

Issue

Section

Original Research Articles