Effects of sildenafil on lipid profile and glycemic control in patients with type 2 diabetes mellitus and metabolic syndrome

Authors

  • Haedar Abdulhafith Al-biati Department of Clinical Pharmacy, College of Pharmacy, University of Bagdad, Baghdad, Iraq
  • Sajida Hussein Ismail Department of Pharmacology and Toxicology, College of Pharmacy, University of Bagdad, Baghdad, Iraq
  • Ahmed Salih Sahib Department of Pharmacology, Al-Kindy College of Medicine, University of Bagdad, Baghdad, Iraq
  • Faris Abdul Kareem Kazaal Department of Internal Medicine, Obesity Therapy and Research Unit, Al-Kindy College of Medicine, University of Bagdad, Baghdad, Iraq
  • Salim Al-Rubaie Department of Internal Medicine, Baghdad Teaching Hospital, Baghdad, Iraq

Keywords:

Sildenafil, Obesity, Type 2 diabetes mellitus, Metabolic syndrome

Abstract

Background: Insulin resistance impairs nitric oxide (NO) bioavailability; obesity promotes a state of metabolic syndrome and damages the vascular endothelium by altering lipid profile. Phosphodiesterase-5 (PDE-5) inhibitors restore NO signaling may improve metabolic parameters through a number of mechanisms. We hypothesized that daily administration of the PDE-5 inhibitor; sildenafil will improve fasting plasma glucose (FPG), triglyceride (TG) levels and body weight, in obese diabetic patients.

Methods: Totally, 25 obese diabetic male patients with metabolic syndrome treated with sildenafil 25 mg daily for 3 months. Body weight, FPG levels, and lipid profile were determined monthly.

Results: Treatment with sildenafil caused a reduction in fasting glucose levels, fasting TGs, cholesterol, low-density lipoprotein (LDL), very-LDL and increased high-density lipoprotein; body weight was significantly reduced.

Conclusion: We have provided the first evidence that sildenafil therapy improve glycemic control, lipid profile and body mass index in diabetic patients with metabolic syndrome.

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Published

2017-01-29

How to Cite

Al-biati, H. A., Ismail, S. H., Sahib, A. S., Kazaal, F. A. K., & Al-Rubaie, S. (2017). Effects of sildenafil on lipid profile and glycemic control in patients with type 2 diabetes mellitus and metabolic syndrome. International Journal of Basic & Clinical Pharmacology, 3(6), 1048–1051. Retrieved from https://www.ijbcp.com/index.php/ijbcp/article/view/1185

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Original Research Articles