Rufinamide: treatment of seizures associated with Lennox–Gastaut syndrome


  • Haritha Allu GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India
  • Prasad R. Muduveti GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India
  • Penugonda Vineela GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India
  • Sathish Kalluri GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India
  • Kuppili V. Saikiran GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India
  • Siddhartha Lolla GIET School of Pharmacy, Rajahmundry, Andhra Pradesh, India


Rufinamide, Lennox–Gastaut syndrome, Epilepsy, Anti-epileptic drugs


Rufinamide (RUF) is FDA-approved for adjunctive management of seizures related with Lennox–Gastaut syndrome (LGS). This new anti-epileptic drug (AED) adds to the AEDs previously used for LGS together with valproic acid, lamotrigine, felbamate, and topiramate. Its mechanism of action includes preventive the excessive firing of sodium-dependent action potentials, but RUF also exhibits a broad spectrum of action in animal models. The plasma concentration of other AEDs does not change by the RUF. Dizziness, nausea, diplopia, and ataxia vomiting and somnolence are most common adverse effects taking place with RUF. Status epilepticus has been reported, but were uncommon (0.9%). A recent randomized, double-blinded, placebo-controlled trial of RUF in patients with LGS and generalized seizures, including atypical absence and tonic-atonic seizures, showed a 32.7% median percentage decreased in total seizures and a 42.5% median percentage decreased in tonic-atonic seizures. RUF also considerably decreased seizure severity. RUF has been studied as adjunctive therapy for partial seizures in adults and adolescents. In a study of three healthy volunteers, an oral dose of 600 mg RUF recognized high absorption and monoexponential elimination with a mean half-life (t½) of 9 hrs. Excretion was mainly renal (85%) and complete (98%) within 7 days.


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How to Cite

Allu, H., Muduveti, P. R., Vineela, P., Kalluri, S., Saikiran, K. V., & Lolla, S. (2017). Rufinamide: treatment of seizures associated with Lennox–Gastaut syndrome. International Journal of Basic & Clinical Pharmacology, 3(6), 937–942. Retrieved from



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