Levofloxacin induced psychosis: a rare case report
Keywords:
Levofloxacin, Acute psychosis, QuinoloneAbstract
Levofloxacin is a commonly prescribed antibiotic for treating bacterial infections in routine clinical practice. A wide range of side-effects have been ascribed to the quinolone group of drugs, the most common being gastrointestinal. Central nervous system is rarely involved; neuropsychiartic complications are among the least reported adverse reactions. We report a rare case of levofloxacin induced acute psychosis in a young male presenting in out-patient department with signs of urinary tract infection along with pneumonitis.
References
Carbon C. Comparison of side effects of levofloxacin versus other fluoroquinolones. Chemotherapy. 2001;47 Suppl 3:9-14.
Kiangkitiwan B, Doppalapudi A, Fonder M, Solberg K, Bohner B. Levofloxacin-induced delirium with psychotic features. Gen Hosp Psychiatry. 2008;30(4):381-3.
Drlica K, Zhao X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev 1997;61(3):377-92.
FDA.gov. Available from: http://www.accessdata.fda.gov. [Last accessed on 2014 Feb 20].
Drugs.com. Available from: http://www.drugs.com/sfx/levofloxacin-side-effects.html. [Last accessed on 2014 Feb 20].
Abouesh A, Stone C, Hobbs WR. Antimicrobial-induced mania (antibiomania): a review of spontaneous reports. J Clin Psychopharmacol. 2002;22(1):71-81.
Raj V, Murthy TV. Levofloxacin induced delirium with psychotic features in a young patient. Med J Armed Forces India. 2013;69(4):404-5.
Slobodin G, Elias N, Zaygraikin N, Sheikh-Ahmad M, Sabetay S, Weller B, et al. Levofloxacin-induced delirium. Neurol Sci. 2009;30(2):159-61.
