Antinociceptive evaluation of anticonvulsant gabapentin with a conventional nonopioid analgesic in phasic and tonic animal model of acute and chronic pain


  • Suruchi Abrol Department of Anaesthesia, Max Super Speciality Hospital, Mohali, Chandigarh, India
  • Saurabh Kansal Department of Pharmacology, Subharti Medical College, Meerut, Uttar Pradesh, India
  • Abhishek Agarwal Department of Ophthalmology, Venkateshwara Institute of Medical Sciences, Gajraula, Uttar Pradesh, India
  • Ruchika Agarwal Intern, BVDUH Medical College, Pune, Maharashtra, India
  • Tarun Goel Department of Paediatrics, Siddhivinayaka Medical Centre, Meerut, Uttar Pradesh, India


Gabapentin, Diclofenac, Nociception, Formalin test


Background: Some antiepileptic drugs have been shown to be clinically efficacious in treatment of neuropathic pain and are being used by clinician.

Methods: This study determined the analgesic effect of gabapentin in rats in biphasic animal pain model of acute and chronic inflammatory pain and compared its potency with a conventional nonopioid analgesic diclofenac.

Results: Per oral administration of gabapentin produced no any marked effect on early phase response of formalin test, but significantly suppressed the late phase response, while diclofenac produced significant anti-nociceptive effect in both phases of formalin test.

Conclusion: Thus, we have observed that gabapentin produced antinociception in second phase of formalin test, which reflects chronic inflammatory pain.


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How to Cite

Abrol, S., Kansal, S., Agarwal, A., Agarwal, R., & Goel, T. (2017). Antinociceptive evaluation of anticonvulsant gabapentin with a conventional nonopioid analgesic in phasic and tonic animal model of acute and chronic pain. International Journal of Basic & Clinical Pharmacology, 3(4), 623–626. Retrieved from



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