DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20183835

Study on antipyretic property of the leaves of Ligustrum robustum

Vanlalhruaii ., Naveen P.

Abstract


Background: Thorough pharmacological experiments on various plants used in traditional medicines are in progress in order to establish their effectiveness and safety. But modern drugs or conventional medicines are often viewed as impersonal, emphasizing crisis intervention. Keeping in view the above idea, the present study is undertaken on the plant Ligustrum robustum to explore its antipyretic property in albino rats.

Methods: Healthy young albino rats weighing between 100-250gm were obtained for the study. The animals were divided into five groups with six animals in each group. Pyrexia was induced by subcutaneous injection of dried yeast in 2% gum acacia in normal saline at a dose of 20ml/kg body weight below the nape of the neck in albino rats. The antipyretic activity of the aqueous extract of Ligustrum robustum was tested by yeast induced method. The data were subjected to ANOVA followed by Dunnett’s ‘t’ test for statistical significance between different groups.

Results: Ligustrum robustum in doses of 100mg/kg, 200mg/kg and 400mg/kg significantly reduced the temperature (p<0.05 to 0.01) in the 3rd and 4th hour after drug administration.

Conclusions: Present study concludes that the aqueous extract of the leaves of Ligustrum robustum showed significant antipyretic property in the standard experimental animal models.


Keywords


Antipyretics, Albino rat, Ligustrum robustum

Full Text:

PDF

References


Subramoniam A. The problems and prospects of plant drug research in India. Pharmacological evaluation of ecotypes in herbal drug development. Indian J Pharmacol. 2001 May 1;33(3):145.

Dev S. Ethnotherapeutics and modern drug development: the potential of Ayurveda. Current Sci. 1997 Dec 10;73(11):909-28.

Subramoniam A, Pushpangadan P. Development of phytomedicines for liver disease. Indian J Pharmacol. 1999 May 1;31(3):166-75.

Beutler B and Beutler BS. The Pathogenesis of fever, Cecil Text book of medicine, Bennett JC and Plum F. W.S. Saunders Company, 20th Ed. Philadelphia; 1996;1533-1535.

Roberts II LJ and Morrow JD. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout, Goodman and Gilman’s; The pharmacological basis of therapeutics, Joel G. Hardman and Lee Limbird: Mc Graw Hill, 10th Ed, New York; 2001:687-732.

Osmaston AE. Oleaceae, Ligustrum robustum, A forest flora for kumaon: Bishen Singh, Mahendra Pal Singh, Dehra Dun;1978:340-341.

Rao SK, Mishra SH. Antiinflammatory and hepatoprotective activities of Sida rhombofolia Linn. Indian J Pharmacol. 1997;29:110-6.

Khosla P, Sangeeta B, Singh J, Srivastava RK. Antinociceptive activity of Azadirachta indica (neem) in rats. Indian J Pharmacol. 2000 Nov 1;32(6):372-4.

Kokate CK. Practical Pharmacognosy. 4th Ed, Vallabh Prakashan, New Delhi;1994:4-29.

Burn JH, Finney DJ and Goodwin LG: Antipyretics and analgesics, Biological standardization, Geoffrey Cumberlege. Amen House, London EC-4. 1952;2:325-31.

Hajare SW, Chandra S, Tandan SK, Sarma J, Lal J, Telang AG. Analgesic and antipyretic activities of Dalbergia sissoo leaves. Indian J Pharmacol. 2000 Nov 1;32(6):357-60.

Gupta MB, Palit TK, Singh N, Bhargava KP. Pharmacological studies to isolate the active constituents from Cyperus rotundus possessing anti-inflammatory, anti-pyretic and analgesic activities. Indian J Med Res. 1971 Jan;59(1):76.

Mukherjee PK, Das J, Saha K, Giri SN, Pal M, Saha BP. Antipyretic activity of Nelumbo nucifera rhizome extract. Indian J Experimental Biol. 1996 Mar;34(3):275-6.

Trease GE and Evans WC: Phenolic compounds and tannins, Pharmacognosy; Bailliere Trindall, 4th Ed, London; 1972:146-148.

Narayana KR, Reddy MS, Chaluvadi MR, Krishna DR. Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian J Pharmacol. 2001 Feb;33(1):2-16.

Mutalik S, Paridhavi K, Rao CM, Udupa N. Antipyretic and analgesic effect of leaves of Solanum melongena Linn. in rodents. Indian J Pharmacol. 2003 Sep 1;35(5):312-5.

Rang HP, Dale MM and Ritter JM: Anti-inflammatory and immunosuppressant drugs, pharmacology: Churchill Livingstone, 4th Ed, New York; 1999:229-247.