DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20183924

Immunosuppressant effect of Boswellia serrata extract on CFA induced arthritis in rats

Sarvesh Singh, Rajendra Kumar, Anil Kumar Saksena, Rishi Pal, Riddhi Jaiswal, Rahul Kumar

Abstract


Background: Rheumatoid arthritis (RA) is an immune-mediated arthropathy, so for the treatment disease modifying antirheumatoid drugs are required. In this study we are evaluating the immunomodulatory property of Boswellia serrata extract (BSE) as an alternative medicine.

Methods: Complete Freund’s adjuvant (CFA), 0.1ml was injected intradermally in the footpad of left hind paw in 36 Wistar rats to induce RA. Animals were divided into 6 groups. BSE in the doses of 45mg/kg, 90mg/kg and 180mg/kg was administered and cyclophosphamide as standard drug. Various parameters as body weight, paw thickness, ankle diameter, paw volume, arthritis index, TNF- α and histopathological changes were analyzed.

Results: Marked reduction in paw thickness, ankle diameter, paw volume, arthritis index and an improved body weight was found in high dose BSE (180mg/kg) group but the effect was lesser than standard drug Cyclophosphamide.

Conclusions: BSE has significant potential as an alternative medicine for treatment of autoimmune diseases like rheumatoid arthritis.


Keywords


Boswellia serrata extract, Complete Freund’s adjuvant, Cyclophosphamide, Rheumatoid arthritis

Full Text:

PDF

References


Firestein GS, McInnes IB. Immunopathogenesis of Rheumatoid Arthritis. Immunity. 2017;46(2):183-96.

Tak PP, Bresnihan B. The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis. Arthritis Rheum. 2000;43(12):2619-33.

Lim H, Lee SH, Lee HT, Lee JU, Son JY, Shin W, et al. Structural Biology of the TNFα Antagonists Used in the Treatment of Rheumatoid Arthritis. Int J Mol Sci. 2018;19(3):768.

Siddiqui MZ. Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview. Indian J Pharm Sci. 2011;73(3):255-61.

Umar S, Umar K, Sarwar AH, Khan A, Ahmad N, Ahmad S, et al. Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis. Phytomedicine. 2014 May 15;21(6):847-56.

Chang Y. Adjuvant polyarthritis. Arthritis Rheum. 1980;23:62-71.

Bendele AM. Animal models of rheumatoid arthritis. J Musculoskel Neuron Interact, 2001;1(4):377-85.

Ji YY, Wang ZD, Wang SF, Wang BT, Yang ZA, Zhou XR, et al. Ischemic preconditioning ameliorates intestinal injury induced by ischemia-reperfusion in rats. World J Gastroenterol. 2015;21(26):8081-8.

Liu HM, Wang KJ. Therapeutic effect of Captopril on rheumatoid arthritis in rats. Asian Pac J Trop Med. 2014;7(12):996-9.

Ebrahimpour S, Fazeli M, Mehri S, Taherianfard M, Hosseinzadeh H. Boswellic Acid Improves Cognitive Function in a Rat Model Through Its Antioxidant Activity: - Neuroprotective effect of Boswellic acid. J Pharmacopuncture. 2017;20(1):10-7.

Singh D, Nainwani R, Gupta A. In-vivo anti-inflammatory and anti-arthritic activity of hydroalcoholic extract of Pongamia Pinnata (L.) Pierre seed. Int J Pharm Pharma Scienc. 2014;6:798-803.

Hartmann RM, Martins MI, Tieppo J, Fillmann HS, Marroni NP. Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid. Dig Dis Sci. 2012 Aug 1;57(8):2038-44.

Yassin N, El-Shenawy MA, Mahdy KA, Gouda NAM, El-Fattah A, Marrie H, et al. Effect of Boswellia serrata on Alzheimer’s disease induced in rats. J Arab Society Med Resea. 2013;8:1-11.

Gupta I, Parihar A, Malhotra P, Gupta S, Lüdtke R, Safayhi H, et al. Effects of Gum Resin of Boswellia serrata in Patients with Chronic Colitis. Planta Med. 2001;67(5):391-5.

Hosseini-Sharifabad M, Kamali-Ardakani R, Hosseini-Sharifabad A. Beneficial effect of Boswellia serrata gum resin on spatial learning and the dendritic tree of dentate gyrus granule cells in aged rats. Avicenna J Phytomed. 2016;6(2):189-97.