DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20183942

Efficacy of 5HT3 receptor antagonist ondansetron antidepressant activity in physical induced albino mice

Janardhan Marupaka, Roopa B., Naveen Kumar T.

Abstract


Background: The objective of this study was to evaluate efficacy of 5HT3 receptor antagonist ondansetron antidepressant activity in physical induced swiss albino mice.

Methods: Study was placebo controlled, randomized laboratory based comparative study with prior permission of Institutional animal ethical committee. Experimental animals were divided in to seven groups as control (distilled water 10ml/kg), standard Fluoxetine two doses (10mg/kg and 20mg/kg) , test drug ondansetron three doses (0.5mg/kg, 1mg/kg and 2mg/kg) and combinations of test and standard (0.5mg/kg + 10mg/kg).The drugs were administered intraperitonium and antidepressant activity was recorded using physically induced depression models tail suspension test and despair swim test.

Results: Ondansetron treated albino mice groups with dose dependent increase of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg showed significant decrease in antidepressant activity and increase in catalepsy score when compared with fluoxetine 10mg/kg and 20mg/kg. Combination doses showed stastically significant antidepressant activity.

Conclusions: The present study indicates ondansetron showed promising antidepressant activity due to its ability to modulate serotonergic system and has proved to be safe in the dose range of 0.5mg/kg, 1mg/kg and 2mg/kg in mice.


Keywords


Antidepressant activity, Albino mice, Ondansetron, Physical induced

Full Text:

PDF

References


Maxine A, Papadakis, Stephen JM. Mood disorders. In: Current Medical Diagnosis and Treatment, 55th Ed. New Delhi. McGraw Hill Education; 2016:1057.

Martin P, Gozlan H, Puech AJ. 5-HT3 receptor antagonists reverse helpless behaviour in rats. Eur J Pharmacol. 1992 Feb 25;212(1):73-8.

Ramamoorthy R, Radhakrishnan M, Borah M. Antidepressant-like effects of serotonin type-3 antagonist, ondansetron: an investigation in behaviour-based rodent models. Behavioural Pharmacol. 2008 Feb 1;19(1):29-40.

Kalra BS, Tayal V, Chawla S. Antidepressant-like activity of tramadol in mice. Indian J Psychiatry. 2008 Jan;50(1):51.

Vogel HG. Antidepressant activity. Drug Discovery and Evaluation: Pharmacological Assays, edited by Vogel HG, 2nd Ed. Germany: Springer - Verlag Berlin Heidelberg; 2002.

Greenshaw AJ. Behavioral pharmacology of 5HT3 receptor antagonist: acritical uptake on therapeutic potential. Trends Pharmacol Sci. 1992;14:265-70.

Bétry C, Etiévant A, Oosterhof C, Ebert B, Sanchez C, Haddjeri N. Role of 5-HT3 receptors in the antidepressant response. Pharmaceuticals. 2011 Apr 7;4(4):603-29.

Blandina PA, Goldfarb JO, Walcott JA, Green JP. Serotonergic modulation of the release of endogenous norepinephrine from rat hypothalamic slices. J Pharmacol Experiment Therapeut. 1991 Jan 1;256(1):341-7.

Zifa E, Fillion G. 5HT receptors. Pharmacol Rev. 1992;44:401-58.

Tripathi KD. Antiemetic, Prokinetic and digestant drugs. Essential of Medical Pharmacology. 8th Ed. New Delhi. Jaypee Brothers medical publishers;2018:716-717.