Assessment of drug related problems and clinical pharmacist interventions in paediatric department of a tertiary care teaching hospital

Authors

  • Deepishka Pemmasani Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University, Anantapuramu, Andhra Pradesh, India
  • Sai Deepak Gali Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University, Anantapuramu, Andhra Pradesh, India
  • Maanasa Arcot Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University, Anantapuramu, Andhra Pradesh, India
  • Durga Prasad T. S. Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University, Anantapuramu, Andhra Pradesh, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20183926

Keywords:

Clinical pharmacist, Drug therapy, Drug related Problems (DRPs), Intervention, Paediatrics

Abstract

Background: Drug-related problems (DRPs) are frequent in hospitalization in pediatrics. The main aim of present investigation is to assess drug related problems and clinical pharmacist interventions in pediatric department of tertiary care hospital.

Methods: It was a prospective, observational and interventional study carried over a period of 6 months.

Results: A total of 66 patients were identified with drug related problems. Among them 31 (42%) were in between 1month–2 years followed by 25 (34%) were in between 2-11 years, 10(24%) were in between 11-18 years of age. 30(45.3%) patients were prescribed with 0-3 drugs followed by 21 (31.3%) were prescribed with 3-5 drugs, 15(23.3%) were prescribed with 6-10 drugs. Most of the DRP’s observed in the study were drug interactions 52(78.78%) [major-19 (36.53%), moderate-27 (5192%) and minor-6(11.53%)] followed by adverse drug reactions 12 (18.18%), and duplication errors were 2 (3.03%). Majority of the clinical pharmacist recommendations were duration change 52 (34.66%), drug change 10(6.66%), dose reduction 2 (1.35%) followed by drug termination 2 (1.33%). Major significance of DRPs were noted high 31(57.96%), whereas 25 (39.8%) were moderate and 8 (12.12%) were minor. The acceptance rate of intervening clinical pharmacist recommendation and change in drug therapy was found to be high in 57 (86.66%) cases while in 9 (13.33%) cases suggestions were accepted but therapy was not changed. There were no cases with neither suggestion were accepted nor therapy changed.

Conclusions: Clinical pharmacist involvement in inpatient pediatric care can significantly help to identify, resolve and prevent the drug related problems. The study concluded that the clinical pharmacist has a significant role in patients care at hospital.

References

Parthasarathy A ED. IAP Textbook of paediatrics 4th ed.Newdelhi: Jaypee publishers 2009 Available at: https://www.jaypeedigital.com/Book/BookDetail?isbn=9788184485806 (Accessed 9th November 2017).

Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE. Developmental pharmacology-drug disposition, action, and therapy in infants and children. N Eng J Med. 2003 Sep 18;349(12):1157-67.

Sanghera N, Chan PY, Khaki ZF, Planner C, Lee KK, Cranswick NE, et al. Interventions of hospital pharmacists in improving drug therapy in children. Drug Safety. 2006 Nov 1;29(11):1031-47.

Emerson technologies, delivering to improve health; 2010. Available at:

https://www.emersonecologics.com/Content/pdf/practicetools/Pediatric_Doses.pdf. Accessed 9th August 2017.

Baena MI, Faus MJ, Fajardo PC, Luque FM, Andres Cabrera FJ, Antonio Zarzuelo FF. Medicine-related problems resulting in emergency department visits. Eur J Clin Pharmacol. 2006;62:387-93.

Blix HS, Viktil KK, Moger TA, Reikvam Å. Characteristics of drug-related problems discussed by hospital pharmacists in multidisciplinary teams. Pharmacy World Sci. 2006 Jun 1;28(3):152.

Blix HS, Viktil KK, Reikvam Å, Moger TA, Hjemaas BJ, Pretsch P, et al. The majority of hospitalised patients have drug-related problems: results from a prospective study in general hospitals. Eur J Clin Pharmacol. 2004 Nov 1;60(9):651-8.

Krahenbuhl-Melcher A, Schlienger R, Lampert M, Haschke M, Drewe J, Krahenbuhl S. Drug-related problems in hospitals: a review of the recent literature. Drug Saf. 2007;30(5):379-407.

Ragesh G. The Study on Assessment and Evaluation of Clinical Phrmacy Servises in Paediatric Inpatients in Tertiary Care Teaching Hospital. Int J Pharm Sci Rev Res. 2015;33(2):16-20.

Dahal PR, Venkataraman R, Fuloria PC. Assessment of clinical pharmacist intervention in tertiary care teaching hospital of Southern India. Asian J Pharmaceut Clin Res. 2013;6(2):258-61.

Jose B, Shareef J, Shenoy R. Assessment of drug related problems and pharmacist intervention in pediatric drug therapy in a tertiary care teaching hospital. Am J Pharm Tech Res. 2016;6(2):209-18.

Rashed AN, Neubert A, Tomlin S, Jackman J, Alhamdan H, AlShaikh A, et al. Epidemiology and potential associated risk factors of drug-related problems in hospitalised children in the United Kingdom and Saudi Arabia. Eur J Clin Pharmacol. 2012 Dec 1;68(12):1657-66.

Viktil KK, Blix HS. The impact of clinical pharmacists on drug‐related problems and clinical outcomes. Basic Clin Pharmacol Toxico. 2008 Mar;102(3):275-80.

Downloads

Published

2018-09-24

How to Cite

Pemmasani, D., Gali, S. D., Arcot, M., & T. S., D. P. (2018). Assessment of drug related problems and clinical pharmacist interventions in paediatric department of a tertiary care teaching hospital. International Journal of Basic & Clinical Pharmacology, 7(10), 1934–1939. https://doi.org/10.18203/2319-2003.ijbcp20183926

Issue

Section

Original Research Articles