DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20183494

Observational study of drug use pattern in indoor patients suffering from major depression admitted in psychiatry department of tertiary care teaching hospital

Vaishali Thakare, Lily Dubey

Abstract


Background: Mental illness is associated with high levels of health service utilization and associated costs. India is among one of the countries with the highest number of people suffering from depression. The data on antidepressant drug utilization in India is sparse. Hence, we planned to analyse the drug use pattern in patients of major depression as per the WHO recommended indicators of drug use.

Methods: This prospective observational study was done to analyze the prescription pattern of hospital psychiatrist in indoor major depression patients. All the patients admitted in psychiatry indoor patient department (I. P. D.) of Dr. D. Y. Patil Hospital, Navi Mumbai were included.

Results: Data of 97 patients was analysed. 55.67% of the cases were from the age group 31-50 years. Total number of antidepressants prescribed was 102(36.82%). Out of antidepressant agents, Selective Serotonin Reuptake Inhibitors (SSRIs) were the most commonly prescribed drugs 70 (68.62%). The most commonly prescribed antidepressant was Sertraline in 35 (34.3%).

Conclusions: The findings of our study were similar to those of other studies conducted to evaluate the use of antidepressants.


Keywords


Depression, Off-label, Prescribing pattern, Polypharmacy

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References


World Health Organization. The World Health Report 2001- Mental Health: New understanding, new hope (Internet). Geneva; 2001.

Math SB, Chandrashekar CR, Bhugra D. Psychiatric epidemiology in India. The Ind J Med Res (Internet). 2012 Nov 21);126(3):183-92.

Murthy R. Mental Health Programme in the 11th Five year plan. The Indian Journal of Medical Research (Internet). 2007 11 (June):707-712.

Sharma P, Das S, Deshpande S. An estimate of the monthly cost of two major mental disorders in an Indian metropolis. Indian J Psychiatry. 2006;48:143-8.

Thakkar KB, Jain MM, Billa G, Joshi A, Khobragade AA. A drug utilization study of psychotropic drugs prescribed in the psychiatry outpatient department of a tertiary care hospital. JCDR. 2013 Dec;7(12):2759.

Organisation for economic cooperation and development. OECD Policy brief - Mental health in OECD countries. Paris: OECD, 2008.

Tinsley JA, Shadid GE, Li H, Offord KP, Agerter DC. Psychotropic prescribing practices and educational needs: a survey of family physicians and psychiatrists. Gen Hosp Psychiat. 1998;20:360-7.

Bouhassira M, Allicar MP, Blachier C, Nouveau A, Rouillon F. Whichpatients receive antidepressants? A 'real world' telephone study. J Affective Disorders 1998;49:19-26.

Mishra A, Swain TR, Mohanty MA. Patterns of prescription and efficacy evaluation of antidepressants in a tertiary care teaching hospital in eastern India. Asian J Pharm Clin Res. 2012;5:19-22.

Ahmad F, Singh PP, Manoj, Kumar A, Gaur RK. Drug Prescribing pattern for major depressive psychosis patients in geriatric clinic of a teaching hospital in northern India. Int J Pharm Pharm Sci. 2013;5(2):269-72.

Practice guideline for the treatment of patients with major depressive disorder. 3rd Ed. Arlington (VA): American Psychiatric Association (APA). 2010:152.

NICE. Depression in adults (update)(CG90). National Institute for Health and Clinical Excellence. National Collaborating Centre for Mental Health; 2009.

Balon R, Mufti R, Arfken CL. A survey of prescribing practices for monoamineoxidase inhibitors. Psychiatric services (Washington, D. C.); 1999.

Furukawa TA, Streiner DL, Young LT. Is antidepressant-benzodiazepine combination therapy clinically more useful? a meta-analytic study. J Affect Disord. 2001;65:173-7.

Smith WT, Londborg PD, Glaudin V, Painter JR. Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression?. J Affe Disorde. 2002 Aug 1;70(3):251-9.

Adli M, Rossius W, Bauer M. Olanzapine in the treatment of depressive disorders with psychotic symptoms. Nervenarzt. 1990;70:68-71.