DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20183487

Study on drug utilization pattern of antihypertensive medication in tertiary care hospital of Telangana, India

K. Vashishta

Abstract


Background: Hypertension is leading cause of deaths in the world. It is the major risk factor for systemic disorders including cardiovascular, renal and brain disorders. A drug utilization review on antihypertensive drugs should be done to determine different classes of antihypertensive medications with respect to diagnosis. Aim was to study drug utilization pattern of antihypertensive medication in a tertiary care hospital, Telangana.

Methods: A cross sectional observational study was done in the patients with hypertension for duration of one year i.e. from April 2017 to May 2018 in the department of Pharmacology at Mallareddy Narayana multispecialty hospital, suraram, Telangana. A total 130 Patients who were suffering with acute, chronic hypertension and admitted in general medicine department and undergoing antihypertensive treatment were included.

Results: A Total of 130 patients with history of hypertension were included. majority of patients i.e., 46.1% (60/130) were among 51-60 years, followed by 24.6% (32/130) patients among 41-50 years., Male predominance 80/130 61.5%) compared to females 50/130 (38.4%). In the Present study, 105(80.7%) prescriptions had Monotherapy prescription and 25/130 (19.2%) has combination of two. The most frequently prescribed drug as monotherapy was Calcium Channel Blockers (CCBs) about 52.3%, Beta blockers constitute about 14.2%, and diuretics about 19%, 9.5% Angiotension Receptor Blockers (ARBs) and alpha-Adrenergic Blocker (AABs), 4.7% ACE inhibitors.

Conclusions: Calcium channel blockers are the highest among the drugs that are used as monotherapy. In combination therapy, diuretic with angiotensin receptor blocker and calcium channel blocker with beta blocker are the frequently prescribed drugs.


Keywords


Antihypertensives, Calcium channel blockers

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References


Longo DL, Fauci SA, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. Harrison’s Principles of Internal Medicine. Eighteenth edition, McGraw-Hill Medical, New York, United States of America; 2012.

Mohan S, Campbell N, Chockalingam A. Time to effectively address hypertension in India. Indian J Med Res. 2013;137(4):627-31.

Yusuf S, Reddy S, Ôunpuu S, Anand S. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001 Nov 27;104(22):2746-53.

National Cardiovascular Disease Database: availablea at: http://www.searo.who.int/india/topics/cardiovascular_diseases/NCD_Resources_Nat ional_CVD_database-Final_Report.pdf?ua=1.

Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Angelantonio ED, Prabhakaran D. Hypertension in India: a systematic review and meta-analysis of prevalence, awareness, and control of hypertension. J Hypertens. 2014;32(6):1170-7.

Chobanian V. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206-52.

Rosendorff C. Treatment of hypertension in the prevention and management of ischemic heart disease: a scientific statement from the American Heart Association Council for High Blood Pressure Research and the Councils on Clinical Cardiology and Epidemiology and Prevention. Circulation 2007;115:2761-8.

Bope TC, Kellerman RD. Conn’s Current Therapy 2013. Saunders-Elsevier, Philadelphia, United States of America; 2013.

Shirley C, Nagavi BG. Impact of community pharmacy basedpatient education on the quality of life of hypertensive patients. Indian J Pharm Educ Res. 2007;41(2):164-9.

Sharma A, Gupta TK, Rathore MS, Chhabra M, Gaur A. Drug utilization Study on Oral Hypertensive Medication Patients and Assessment of Medication Adherence to JNC-8 Guidelines in North Indian Tertiary Care Hospital: A Cross-Sectional Study.

Kaur S, Gupta S, Kumar D, Lal M, Gilani Z. Prescribing pattern of antihypertensive drugs in a tertiary care hospital in Jammu: a descriptive study. JK-Practitioner. 2012 Oct;17(4):38-41.

Mishra R, Kesarwani P, Keshari SS. Prescription pattern of antihypertensive drugs in a tertiary care teaching hospital. Int J Med Sci Public Health. 2017 Apr 1;6(4):684.

Datta S. Utilization study of antihypertensives in a South Indian tertiary care teaching hospital and adherence to standard treatment guidelines. J Bas Clin Pharma. 2016 Dec;8(1):33.

Daniel N, Sharma R, Shastry C. Drug utilization pattern of antihypertensives in a tertiary care hospital in south India. World J Pha Pharmaceut Sci. 2014;3(10).

Nachiya JRA, Parimalakrishnan S, Rao RM. Study on drug utilization pattern of antihypertensive medications on out-patients and inpatients in a tertiary care teaching hospital: A cross sectional Study. Afr J Pha Pharmacol. 2015 Mar 22;9(11):383-96.