DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20182496

Influence of Eclipta alba on serum alanine aminotransferase and aspartate aminotransferase activity in rabbits

B. P. Kale, Mujawar Jahir Rauf

Abstract


Background: Paracetamol is a recognized antipyretic, analgesic drug which produces hepatic necrosis in high doses. Eclipta alba elaborates a vast array of biologically active compounds that are chemically diverse and structurally complex.

Methods: Randomized open controlled experimental study Estimated levels of Serum aspartate aminotransferase (AST), Serum alanine aminotransferase (ALT) and Hepatoprotective action of in High doses of Paracetamol on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity.

Results: ALT in all the groups including Control group (A) was (51.8±4.56IU/L). Paracetamol treated group (B) the ALT level increased at 48 hours and continued to be high up to 60 days (136.4±20.73IU/L) then decreased to (113.7±11.35IU/L) at 90 days. AST in all the groups including Control group (A) was (22.5±1.23IU/L). Appropriate antioxidant in appropriate doses as a matter of routine whenever hepatotoxic or potentially hepatotoxic drugs are prescribed. In Paracetamol treated group (B) the AST level increased at 48 hours and continued to be high up to 60 days (99.4±9.73IU/L) then decreased to (85.4±7.39IU/L) at 90 days.

Conclusions: Appropriate antioxidant in appropriate doses as a matter of routine whenever hepatotoxic or potentially hepatotoxic drugs are prescribed.


Keywords


Alanine aminotransferase, Eclipta alba, Paracetamol

Full Text:

PDF

References


Irshad M, Chaudhuri O. Oxidant - antioxidant system: Role and significance in human body. Indian J of Experi Biolog. 2002;40(9):1233-9.

Ramadoss S, Kannan K, Balamurugan K, Jeganathan NS, Manavalan R. Evaluation of Hepato-Protective Activity in the Ethanolic Extract of Sida Rhombifolia Linn. Against Paracetamol Induced Hepatic Injury in Albino Rats. Resea J of Pharma Bio and Che Scienc. 2012;3(1):497-502.

Senthil K, Senthil KL. Hepatoprotective Effects of 50% Ethanolic Extract of Ficus hispida Linn Against CCl4 Induced Hepatotoxicity in Rats. Euro J of Biological Scienc. 2012;4(1):01-4.

Dalal S, Kataria S, Sastry K, Rana SVS. Phytochemical Screening of Methanolic Extract and Antibacterial Activity of Active Principles of Hepatoprotective Herb, Eclipta alba. Ethnobotanical Leaflets. 2010;14(2):248-58.

Joel GH, Lee EL. Goodman and Gilmans. The Pharmacological Basis of Therapeutics. Analagisc-antipyritic and anti-inflammatory agents. McGraw- Hill; 2011:983.

Kadri A, Gharsallah N, Damak M, Gdoura R. Chemical composition and in vitro antioxidant properties of essential oil of Ricinus communis L. J of Med Plan Resear. 2011 Apr 18;5(8):1466-70.

Parasuraman S, Raveendran S, Kesavan R. Blood sample collection in small laboratory animals. J of Pharmacol and Pharmacotherap. 2010;1(2):87-93.

Pithayanukul P, Lapett B, Bavovada R, Pakmanee N, Suttisri R. Inhibition of proteolytic and hemorrhagic activities by ethyl acetate extract of Eclipta prostrata against Malayan Pit Viper Venom. Pharmaceutical Biology. 2007;45(2):282-8.

Samiulla S, Mundkinaeddu S, Shivanna Y, Arun C, Keerthi M, Prashanth D, et al. Trypsin inhibitory effct of Wedlolactone and Demethylwedelolactone. Phytoter Res. 2003;17(4):420-1.

Lee MK, Ha NR, Yang H, Sung SH, Kim YC. Stimulatory constituents of Eclipta prostrata on mouse osteoblast differentiation. Phytotherapy Research. 2009 Jan 1;23(1):129-31.