DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20184316

Accentuation of general anaesthetic activity of ketamine by glutamate NMDA (N-methyl D-aspartate) receptor antagonist

M. S. Umamageswari, Vasanthan ., Nikitha S. Kumar

Abstract


Background: The aim of the present study was to evaluate the potentiation of general anaesthetic activity of ketamine by NMDA receptor antagonist ‘amantadine’ in wistar albino rats.

Methods: The wistar albino rats of either sex were divided into three groups of five animals in each group. Group I received ketamine 80mg/kg, group II received ketamine 40mg/kg along with amantadine 40mg/kg and group III received ketamine 80mg/kg along with amantadine 40mg/kg to evaluate the potentiation of general anaesthetic effect of ketamine. The sleep latency time and the total sleeping time were measured in all the three groups.

Results: The sleep latency time of group III is significantly decreased (p <0.035) and as equal to that of group II when compared to group I. The sleeping time of group III is significantly increased (p <0.001) when compared to group I.

Conclusions: Amantadine - the NMDA receptor antagonist potentiates the general anaesthetic activity of ketamine.


Keywords


Amantadine, General anaesthetic effect, Ketamine, NMDA receptor antagonist

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