DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20181641

A prospective randomised open labelled comparative study of anti inflammatory effects of topical 5% benzoyl peroxide gel vs topical 4% nicotinamide gel for grade I-II acne in a tertiary care hospital

Ashok Kumar S. N., Madan Mohan N. T., Shwetha H., Shanmukananda P., Veena D. R., Upasana Dube

Abstract


Background: Acne vulgaris is a dermatological disorder characterised by formation of comedones and inflammatory lesions. The treatment of acne basically involves reduction of lesions. Benzoyl peroxide, in concentrations of 5%, 10%, and 20%, has been used effectively in the treatment of acne for more than 20 years. Nicotinamide/ Niacinamide is a newly-approved anti-acne drug with a potent anti-inflammatory effect. The present study assessed the efficacy of 5% Benzoyl peroxide gel in comparison to 4% Nicotinamide gel for topical treatment of mild to moderate acne vulgaris.

Methods: In this study, the patients with mild to moderate acne vulgaris with inflammation were divided into two groups, group I was treated with topical 5% Benzoyl peroxide gel whereas topical Nicotinamide gel was given to the group II. Assessment of efficacy was done by total lesion counting according acne global severity index, the results were compared at the end of 2 weeks and 4 weeks with the baseline values.

Results: At the end of this study, it was found that the reduction of inflammatory and total percentage of decrease in counts of lesions from baseline were highly significant in both the groups (p<0.001), between the groups, differences were statistically significant (p<0.001), therefore 5% Benzoyl peroxide gel has better efficacy than 4% Nicotinamide gel.

Conclusions: Benzoyl peroxide is more efficacious than 4 % Nicotinamide gel in mild to moderate acne.


Keywords


Acne vulgaris, Comedones, Inflammatory

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References


Katsambas AD, Stefanaki C, Cunliffe WJ. Guidelines for treating acne. Clin Dermatol. 2004;22:439-44. PMID: 15556732.

Healy E, Simpson N. Acne vulgaris. BMJ. 1994;308:831-3. PMID: 8167492

White GM. Acne therapy. In: James WD, Cockerell CJ, Dzubow LW, Paller AS, Yancey KB. Advances in dermatology. St Louis: Mosby; 1999:29-59.

Bissett DL, Oblong JE, Berge CA. Niacinamide: A B Vitamin that improves aging facial skin appearance. Dermatol Surg. 2005;31:860-5. PMID: 16029679

Draelos ZA, Matsubara A, Smiles K. The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther. 2006;8:96-101. PMID: 16766489

Ray C, Trivedi P, Sharma V. Acne and its treatment lines. Int J Res Pharma Bio. 2013;3:1-16.

Rathi SK. Acne vulgaris treatment: The current scenario. Indian J Dermatol. 2011;56:7-13.

Kraft J, Freiman A. Management of acne. CMAJ. 2011;183:E430-435.

Wozniacka A, Sysa-Jedrzejowska A, Adamus J, Gebicki J. Topical application of NADH for the treatment of rosacea and contact dermatitis. Clin Exp Dermatol. 2003;28:61-3. PMID: 12558633

Rallis E, Verros C, Katoulis A, Katsarou A. Topical 5% Benzoyl peroxide and 3% Erythromycin gel: Experience with 191 patients with papulopustular acne. Acta Dermatovenerol Croat. 2013;21(3):160-7.

Mills OH, Kligman AM, Pochi P, Comite H. Comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris. International Journal of Dermatology. 1986 Dec 1;25(10):664-7.

Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inelammatory acne vulgaris. International Journal of Dermatology. 1995 Jun 1;34(6):434-7. PMID: 7657446