DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20175688

Usage of lipid-lowering drugs such as atorvastatin and rosuvastatin in the management of hyperlipidemia in multiple vessel wall block patients

Sivaraj R., Umarani S.

Abstract


Background: Multi-vessel coronary artery disease (CAD) is a disease stage in which at least two or three of the epicardial coronary arteries is involved with atherosclerosis of significant severity. The multi-vessel disease is often associated with a higher burden of comorbidities, left ventricular dysfunction, and cardiovascular risk. Dyslipidaemia is the commonest cause of the blood vessel diseases and their incidence has been rising all over the world thereby increasing the morbidity and mortality due to cardiovascular diseases. Dyslipidaemia is also one of the component of metabolic syndrome along with another group of cardiovascular risk factors such as high blood pressure (BP), abdominal obesity, and insulin intolerance, whose concurrent appearance increases the risk of atherosclerotic cardiovascular disease. To compare the efficacy of atorvastatin and rosuvastatin in the management of hyperlipidaemia. To compare the dose-related efficacy of statins on lipid goal achievement in patients with hyperlipidaemia.

Methods: This prospective, randomized, single-blinded interventional study was conducted for a period of 1 year [2014-1015] in medicine OPD in Rajah Muthiah Medical College and Hospital. A total number of 100 patients with diagnosed multiple vessel blocks were included in this study. Among them, 50 patients were randomized to group A. 50 patients were selected to group B. 50 patients of the group A are treated with Atorvastatin up 10 mg once daily for 8 weeks. 50 patients of group B were treated with Rosuvastatin up to 10mg/day. For 8 weeks the results were analysed accordingly.

Results: Even though both rosuvastatin 10mg/day and atorvastatin 10mg/day produced a reduction in total cholesterol (p<0.001) significantly, rosuvastatin produced a reduction in LDL levels (p<0.001) more significantly than atorvastatin 10mg/day.

Conclusions: Rosuvastatin produces a greater reduction in serum LDL-C levels and should, therefore, be preferred over atorvastatin. Both the treatment regimens significantly decreased TC, TG, LDL C, VLDL C, but the reduction was more and statistically significant in Rosuvastatin when compared with atorvastatin-treated group at the end of 8 weeks.


Keywords


Atorvastatin, Coronary angioplasty LDL, Dyslipidemia, HDL, Multiple vessel blocks, Rosuvastatin

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