A comparative study of the antidepressant effect of ondansetron and granisetron on Albino mice

Authors

  • Mansi J. Shah Department of Pharmacology, JJMMC, Davangere, Karnataka, India
  • Geetha M. Department of Pharmacology, JJMMC, Davangere, Karnataka, India
  • Rahul H. D. Department of Pharmacology, JJMMC, Davangere, Karnataka, India
  • Shashikala G. H. Department of Pharmacology, JJMMC, Davangere, Karnataka, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20175219

Keywords:

Antidepressants, Granisetron, Ondansetron

Abstract

Background: Ondansetron and granisetron are selective 5-HT receptor antagonists used as antiemetics. The present study as aimed at comparing the antidepressant activity of ondansetron and granisetron in animal experimental models.

Methods: The study was done after obtaining approval from the institutional animal ethical committee of JJM Medical college, Davangere and CPCSEA. A total of 24 mice of either sex and of weight between 20-40g were included in the study. The antidepressant activity of ondansetron and granisetron was evaluated in mice using forced swim test model (FST) and tail suspension test model (TST). In both the experimental models animals were divided into 4 groups and received the following drugs- Group 1 (control) - normal saline 10mg/kg i.p, Group 2 (standard)-fluoxetine 10mg/kg i.p, Group 3(test drug 1), ondansetron 2mg/kg i.p, Group 4 (test drug 2)- granisetron 0.5mg/kg i.p. The duration of immobility was noted and compared amongst the 4 groups in both the models 60 min after drug administration. The observations were analysed using ANOVA (one way) and post hoc Tukey’s test.

Results: The test drugs showed significant reduction in duration of immobility in both the models. In FST and TST models, granisetron (0.5mg/kg i.p) showed a significant reduction in immobility period of 10.33 sec and 67 secs respectively when compared to ondansetron (2mg/kg i.p) and the standard drug fluoxetine (10mg/kg i.p).

Conclusions: The results of study suggest that granisetron may be useful as a potential candidate for treatment of depression. Hence further animal studies with different model for depression and clinical studies should be conducted in order to choose the better drug for treatment PONV which is often associated with depression.

References

Fauci AS, Braunward E, Kaspler D, Loscalzo J. Harrisons Principals Of Internal Medicine 17th Ed, Vol 2, New York: Mc Graw Hill; 2008:2717-2718.

Rechelson E. Pharmacology of Antidepressants. Mayo Clinic Proceedings. 2011;76:516-27.

Madhav Sm. Epidemiological Study of Prevalence of Mental Disorders in India. Indian Journal of Community Medicine. 2001;26(4):198-200.

Srivastava SK. Anti-Depressant Activity of Ondansetron, A 5-Ht3 Antagonist, Indian J Pharmacol. 1998;30:411.

Cecile B, Alan LP, Adeline E, Bjarke E, Connie S, Nasser H. The Rapid Recovery Of 5ht. Cell Firing Induced by The Antidepressant Vortioxetine Involves 5ht3 Receptor Antagonism. The International J of Neuropsychopharmacology. 2009;16:1115-27.

Porsolt RD, Pichon ML, Jalfre M. Depression: A New Animal Model Sensitive to Antidepressant Treatments Nature. 1977;266:730-2.

Sanmukhani J, Anovadiya A, Tripathi CB. Evaluation of Antidepressant Like Activity of Curcumin And Its Combination With Fluoxetine And Imipramine: An Acute And Chronic Study. Drug Res. 2011;68(5):769-75.

Santosh P, Venugopal R, Nilakash A. Antidepressant Activity of Methanolic Extract of Passiflora Foetida Leaves In Mice. Int J Pharm Pharm Sci. 2011;3(1):112-5.

Sterul, Chermat R, Thierry B. Simon P. The Tail Suspension Test: A New Method for Screening In Mice. Psychopharmacology (Berl). 1985;85(3):367-70.

Porsolt RD, Bertin A, Jalfre M. Behavioural despair In Mice: A Primary Screening Test for Antidepressants. Arch Int Pharmacodyn Ther. 1977;229(2):327-36.

Thierry B, Steru L, Simon P, Porsolt RD. The tail suspension test: ethical considerations. Psychopharmacology. 1886;90(2):284-5.

Rajkumar R, Mahesh R. The auspicious role of the 5-HT3 receptor in depression. A probable neuronal target? J Psychopharmacol. 2010;24:455-69.

Brunton LL, Chabner AB, Knollmann CB. Goodman and Gilman’s, The Pharmacological Basis of Therapeutics, 12th Ed, McGraw-Hill, New York. 2011:1345.

Downloads

Published

2017-11-23

How to Cite

Shah, M. J., M., G., H. D., R., & G. H., S. (2017). A comparative study of the antidepressant effect of ondansetron and granisetron on Albino mice. International Journal of Basic & Clinical Pharmacology, 6(12), 2922–2925. https://doi.org/10.18203/2319-2003.ijbcp20175219

Issue

Section

Original Research Articles