Pramipexole with leuprolide: a treatment strategy for PGAD

Authors

  • Rajnish Raj Department of Psychiatry, Government Medical College, Patiala, Punjab, India
  • Nisha Bhagat Department of Obstetrics and Gynecology, Government Medical College, Patiala, Punjab, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20172757

Keywords:

Impulse-control disorder not otherwise specific, Leuprolide, Non-paraphilic sexual addiction, Persistent genital arousal disorder, Restless genital syndrome

Abstract

Persistent genital arousal disorder (PGAD) is described as the spontaneous, intrusive, and unwanted genital arousal in the absence of sexual interest and desire. Whether, its etiology is central or peripheral neurovascular in nature, it is still unclear. However, patient presents with symptoms of persistent engorgement of genital erectile and vascular tissue. The majority of women report PGAD as distressing. The symptoms usually occur in females in the age group 25-58 years especially in perimenopausal phase. The case is reported of PGAD in 19-year old female who was treated successfully with Pramipexole and Leuprolide.

References

Leiblum SR, Nathan SG. Persistent sexual arousal syndrome- A newly discovered pattern of female sexuality. J Sex and Marital Therapy. 2001;27(4):365-80.

Thorne C, Stuckey B. Pelvic congestion syndrome presenting as persistent genital arousal: a case report. J Sex Med. 2008;5:504-8.

Kamatchi R, Ashley-Smith A. Persistent genital arousal disorder in a male: a case report and analysis of the cause. Br J Med Psychol. 2013;6:30-1.

Leiblum S. Persistent genital arousal disorder: what it is and what it isn’t. Contemp Sex. 2006;40:8-13.

Feigenbaum F, Boone K. Persistent genital arousal disorder caused by spinal meningeal cysts in the sacrum. Obstet Gynecol. 2015;126:839-43.

Komisaruk BR, Lee HJ. Prevalence of sacral spinal (Tarlov) cysts in persistent genital arousal disorder. J Sex Med. 2012;9:2047-56.

de Magalhaes FJ, Kumar MT. Persistent genital arousal disorder following selective serotonin reuptake inhibitor cessation. J Clin Psychopharmacol. 2015;35:352-4.

Robyn A, Jackowich BA, Leah Pink MN, Adult NP, Gordon A, Pukall CF. Persistent Genital Arousal Disorder: A Review of Its Conceptualizations, Potential Origins, Impact, and Treatment. Sex Med Rev. 2016;4(4):329-42.

Aquino CC, Mestre T, Lang AE. Restless Genital Syndrome in Parkinson Disease. JAMA Neurol. 2014;71(12):1559-61.

Amsterdam A, Abu‐Rustum N, Carter J, Krychman M. Persistent sexual arousal syndrome associated with increased soy intake. The journal of sexual medicine. 2005 May 1;2(3):338-40.

Elkins GR, Ramsey D, Yu Y. Hypnotherapy for persistent genital arousal disorder: a case study. Int J Clin Exp Hypn. 2014;62:215-23.

Nazik H, Api M, Aytan H, Narin R. A New medical treatment with botulinum toxin in persistent genital arousal disorder: Successful treatment of two cases. Journal of sex and marital therapy. 2014 May 4;40(3):170-4.

Waldinger MD, de Lint GJ, Venema PL, van Gils AP, Schweitzer DH. Successful transcutaneous electrical nerve stimulation in two women with restless genital syndrome: the role of A-delta and C-nerve fibers. J Sex Med. 2010;7:1190-9.

Korda JB, Pfaus JG, Kellner CH, Goldstein I. Persistent genital arousal disorder (PGAD): Case report of long‐term symptomatic management with electroconvulsive therapy. The journal of sexual medicine. 2009 Oct 1;6(10):2901-9.

Yero SA, McKinney T, Petrides G, Goldstein I, Kellner CH. Successful use of electroconvulsive therapy in 2 cases of persistent sexual arousal syndrome and bipolar disorder. The journal of ECT. 2006 Dec 1;22(4):274-5.

Korda JB, Pfaus JG, Goldstein I. Persistent Genital Arousal Disorder (pgad): A case report in a woman with lifelong PGAD where serendipitous administration of varenicline tartrate resulted in symptomatic improvement. The Journal of Sexual Medicine. 2009 Sep 1;6:395-6.

Deka K, Dua N, Kakoty M, Ahmed R. Persistent genital arousal disorder: Successful treatment with leuprolide (antiandrogen). Indian J Psychiatry. 2015;57:326-8.

Rosenbaum TU. Physical therapy treatment of persistent genital arousal disorder during pregnancy: a case report. J Sex Med. 2010;7:1306-10.

Goldmeier D, Sadeghi-Nejad H, Facelle TM. Persistent genital arousal disorder. In: Binik YM, Hall KSK, eds. Principles and practice of sex therapy. 5th Ed. New York, NY: Guilford Press; 2014:263-279.

Leiblum S. Persistent genital arousal disorder. In: Leiblum S, editor. Principles and Practice of Sex Therapy. New York, NY: Guilford Press; 2005:54-83.

The ICD-10. International classification of mental and behavioural disorders. Clinical description and diagnostic guidelines. 10th Ed. Geneva: World Health Organization; 2002.

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Revised 4th Ed. Washington, DC: Author; 2000.

Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown obsessive compulsive scale: I. Development, use, and reliability. Archives of general psychiatry. 1989 Nov 1;46(11):1006-11.

Bjelland I, Dahl AA, Haugg TT, Neckelmann D. The validity of the hospital Anxiety and Depression Scale: an update literature review. J Psychosom Res. 2002;52:69-77.

Beneke M, Rasmus W. ‘Clinical global impressions’ (ECDEU): some critical comments. Pharmacopsychiatrie. 1992;25:171-6.

Schawartz SA, Abramowitz JS. Are nonparaphilic sexual addictions a varaiant of obsessive-compulsive disorder? A pilot study. Cog Behav Practice. 2003;10:373-8.

Hollander E, Wong CM. Introduction: Obsessive-compulsive spectrum disorder. J Clin Psychiatry. 1995;56(4):3-6.

Krueger RB, Kaplan MS. The paraphilic and hypersexual disorders. J Psychiatric Pract. 2001;7:391-403.

Leiblum SR, Goldmeier D. Persistent genital arousal disorder in women: case reports of association with anti-depressant usage and withdrawal. J Sex Marital Ther. 2008;34:150-9.

Filler A. Diagnosis and treatment of pudendal nerve entrapment syndrome subtypes: imaging, injections, and minimal access surgery. Neurosurg Focus. 2009;26:1-14.

Leiblum SR, Goldmeier D. Persistent genital arousal disorder in women: case reports of association with anti-depressant usage and withdrawal. J Sex Marital Ther. 2008;34:150-9.

Bilgic A, Gurkan K, Turkoglu S. Excessive masturbation and hypersexual behavior associated with methylphenidate. J Am Acad Child and Adolsc Psychiatry. 2007;46:789-90.

Uitti RJ, Tanner CM, Rajput AH. Hypersexuality with antiparkinsonian therapy. Clin Neuropharmacol. 1989;12:375-83.

Lasky-Su JA, Faraone SV, Glatt SJ, Tsuang MT. Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet Neuropsychiatric Genet. 2005;133:110-5.

Kafka M. Hypersexual disorder: a proposed diagnosis for DSM-V. Arch Sex Behav. 2010;39:377-400.

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Published

2017-06-23

How to Cite

Raj, R., & Bhagat, N. (2017). Pramipexole with leuprolide: a treatment strategy for PGAD. International Journal of Basic & Clinical Pharmacology, 6(7), 1828–1832. https://doi.org/10.18203/2319-2003.ijbcp20172757

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Section

Case Reports