Effect of flunarizine on memory function by using step down passive avoidance test in albino rats

Authors

  • Vinod Shinde Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra, India
  • Radha Yegnanarayan Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra, India
  • Khyati Doshi Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra, India
  • Akhil Agarwal Department of Pharmacology, Smt. Kashibai Navale Medical College and General Hospital, Narhe, Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20164408

Keywords:

Flunarizine, Fluoxetine, Memory, Step down avoidance test

Abstract

Background: Aim of the study was to evaluate effect of flunarizine on memory function by using step down passive avoidance test in albino rats.

Methods: The study approved by IAEC was conducted using 24 albino rats (n= 6 in each group). Effect of normal saline (0.1 ml/100g), fluoxetine (10 mg/kg, intraperitoneally (ip)), and flunarizine (2 and 10 mg/kg, ip) on memory retrieval in rats was evaluated by using Step-down passive avoidance test. One day prior to conducting the test, each rat was trained to stay on central shock free zone platform (SFZ) for at least 90s. For the training, animals were applied shock of 15s every time when the rat stepped down placing all the paws on the grid floor. On the consecutive day retention of the memory was tested thirty minutes after administration of all test drugs. Step down latency (SDL) and number of mistakes was observed for a period of 5 min in all rats.

Results: The data was analyzed by one-way analysis of variance (ANOVA) and Student’s t-test and P <0.05 was considered significant. Mean Step down latency was significantly increased in fluoxetine (10mg/kg, i.p) group as compared to the normal saline (P<0.05). SDL was increased in flunarizine (10mg/kg, i.p) group but it was not statistically significant (p>0.05). Number of mistakes was reduced in both fluoxetine and flunarizine (10mg/kg, i.p) group and was statistically significant when compared to vehicle treated group.

Conclusions: The results of the present study indicate beneficial effects of flunarizine in memory retrieval in albino rats.

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Published

2016-12-24

How to Cite

Shinde, V., Yegnanarayan, R., Doshi, K., & Agarwal, A. (2016). Effect of flunarizine on memory function by using step down passive avoidance test in albino rats. International Journal of Basic & Clinical Pharmacology, 6(1), 30–34. https://doi.org/10.18203/2319-2003.ijbcp20164408

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Original Research Articles