Neuroprotective effect of secretin in chronic hypoxia induced neurodegeneration in rats

Authors

  • Gowtham Padmanaban Department of Pharmacology, Adhiparaskathi Institute of Medical Sciences, Melmaruvathur, Tamilnadu, India
  • M. K. Kayalvizhi Department of Pharmacology, Adhiparaskathi Institute of Medical Sciences, Melmaruvathur, Tamilnadu, India
  • Kalyanasundaram Kasiviswanathan Department of Pharmacology, Chettinad Hospital and Research Institute, Tamilnadu, India
  • Ruckmani Arunachalam Department of Pharmacology, Chettinad Hospital and Research Institute, Tamilnadu, India
  • Vishnu Kumar Urkavalan AMR Pharma Pvt Ltd, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2319-2003.ijbcp20170318

Keywords:

Anti-oxidant, Hypoxia, Secretin, Hemoglobin, Neuroprotectant

Abstract

Background: Hypoxia is a condition in any stage in the delivery of oxygen to cells which include decreased partial pressures of oxygen, less diffusion of oxygen in the lungs, insufficient hemoglobin, inefficient blood flow to the end tissue, and breathing rhythm. Secretin is an amino acid which plays proper functioning of gastro intestinal system.

Methods: The current study was conducted to evaluvate the effect of exogenously administrated secretin on chronic hypoxic damage of brain in rat model. Experimental design consists of control animals, Control animals + secretin hypoxia exposed animals; hypoxia exposed animals +secretin (20ng/kg.bw).

Results: The results of this study point to a possible role of Secretin as neuroprotectant.

Conclusions: Further research on secretin needs to be conducted in order to confirm the deductions made by this study.

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Published

2017-01-28

How to Cite

Padmanaban, G., Kayalvizhi, M. K., Kasiviswanathan, K., Arunachalam, R., & Urkavalan, V. K. (2017). Neuroprotective effect of secretin in chronic hypoxia induced neurodegeneration in rats. International Journal of Basic & Clinical Pharmacology, 6(2), 298–302. https://doi.org/10.18203/2319-2003.ijbcp20170318

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Original Research Articles